{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:26:45Z","timestamp":1787243205144,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"926","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This is the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour of the pancreas manifesting with severe hypercalcaemia during pregnancy. Measurement of PTHrP was useful in both the diagnosis and follow up of our patient and should be considered in the diagnostic workup of patients with unexplained hypercalcaemia. A raised PTHrP concentration is a strong indicator of malignancy.<\/jats:p>","DOI":"10.1136\/pmj.78.926.752","type":"journal-article","created":{"date-parts":[[2002,12,31]],"date-time":"2002-12-31T22:56:24Z","timestamp":1041375384000},"page":"752-754","source":"Crossref","is-referenced-by-count":38,"title":["Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure"],"prefix":"10.1093","volume":"78","author":[{"given":"P","family":"Abraham","sequence":"first","affiliation":[{"name":"Departments of Endocrinology, Aberdeen Royal Infirmary , Foresterhill, Aberdeen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Ralston","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Aberdeen Royal Infirmary , Foresterhill, Aberdeen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hewison","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Birmingham, Queen Elizabeth Hospital , Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W D","family":"Fraser","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Royal Liverpool University Hospital , Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Bevan","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Aberdeen Royal Infirmary , Foresterhill, Aberdeen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,12,1]]},"reference":[{"key":"2023042418232477600_R1","first-page":"1028","article-title":"Primary hyperparathyroidism during pregnancy.","volume":"110","author":"Kelly","year":"1991","journal-title":"Surgery"},{"issue":"3 pt 2","key":"2023042418232477600_R2","first-page":"496","article-title":"Hypercalcemic crisis in pregnancy associated with excessive ingestion of calcium carbonate antacid (milk-alkali syndrome): successful treatment with hemodialysis.","volume":"78","author":"Kleinman","year":"1991","journal-title":"Obstet Gynecol"},{"issue":"5 pt 2","key":"2023042418232477600_R3","first-page":"841","article-title":"Parathyroid carcinoma during pregnancy.","volume":"96","author":"Montoro","year":"2000","journal-title":"Obstet Gynecol"},{"key":"2023042418232477600_R4","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.3616618","article-title":"A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.","volume":"237","author":"Suva","year":"1987","journal-title":"Science"},{"key":"2023042418232477600_R5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jbmr.5650040115","article-title":"Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy.","volume":"4","author":"Ralston","year":"1989","journal-title":"J Bone Miner Res"},{"key":"2023042418232477600_R6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1530\/eje.0.1370402","article-title":"Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study.","volume":"137","author":"Ardawi","year":"1997","journal-title":"Eur J Endocrinol"},{"key":"2023042418232477600_R7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2265.1989.tb01288.x","article-title":"Parathyroid hormone-related protein in hypercalcaemia of malignancy.","volume":"31","author":"Martin","year":"1989","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2023042418232477600_R8","first-page":"556","article-title":"Circulating vitamin D metabolites and hypercalcaemia of malignancy.","volume":"106","author":"Ralston","year":"1984","journal-title":"Acta Endocrinol (Copenh)"},{"key":"2023042418232477600_R9","first-page":"801","article-title":"Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy.","volume":"76","author":"Schilling","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2023042418232477600_R10","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJM198012113032401","article-title":"Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups.","volume":"303","author":"Stewart","year":"1980","journal-title":"N Engl J Med"},{"key":"2023042418232477600_R11","first-page":"556","article-title":"Humoral hypercalcemia of cancer. 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