{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:22:54Z","timestamp":1759335774068},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"929","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and aims<\/jats:title>\n                  <jats:p>Given its role in mediating inflammation, the use of urinary interleukin-8 (IL-8) was assessed in the non-invasive diagnosis of acute and chronic inflammatory diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>IL-8 was measured by an enzyme linked immunosorbent assay in random urine samples (1 ml each) carrying code numbers and taken from 208 patients: 177 adults and 31 children presenting with a range of active or inactive inflammatory conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the appropriate controls and in patients with inactive inflammation, the median urinary IL-8 levels ranged from 7\u201312 pg\/ml, compared with 104 pg\/ml in active ulcerative colitis (p = 0.002), 54 in active Crohn\u2019s disease (p = 0.025), 93 in active rheumatoid arthritis (p = 0.001), 107 in acute cholecystitis (p&amp;lt;0.0001), 127 in acute appendicitis (p = 0.0001), and 548 pg\/ml in urinary tract infection (p&amp;lt;0.0001). Children with non-viral inflammation\/infection also had higher IL-8 values (median, 199 pg\/ml; p = 0.0001) than those with viral infection (median, 7 pg\/ml) or non-specific conditions (median, 10 pg\/ml). In the study group as a whole urinary IL-8 values correlated positively with peripheral blood white cell count (r = 0.32; p &amp;lt; 0.001), erythrocyte sedimentation rate (r = 0.41; p&amp;lt;0.001), and C-reactive protein (r = 0.33; p&amp;lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Taking the appropriate clinical situation into account, urinary IL-8 measurement helps in the non-invasive assessment of active inflammation in at least a number of common acute and chronic conditions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/pmj.79.929.159","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T23:08:34Z","timestamp":1050448114000},"page":"159-163","source":"Crossref","is-referenced-by-count":24,"title":["Urinalysis for interleukin-8 in the non-invasive diagnosis of acute and chronic inflammatory diseases"],"prefix":"10.1093","volume":"79","author":[{"given":"A S","family":"Taha","sequence":"first","affiliation":[{"name":"Crosshouse Hospital , Kilmarnock"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Grant","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Reproductive Biology , Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Kelly","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Reproductive Biology , Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2023042409412356100_R1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(00)03224-4","article-title":"Calprotectin, a faecal marker of organic gastrointestinal 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