{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:56:14Z","timestamp":1757613374614,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2023,4,12]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>A 56-year-old woman developed progressive subacute lower limb weakness with sensory and autonomic abnormalities. She had received a living-donor kidney transplantation 21 years before for end-stage chronic kidney disease and took mycophenolate mofetil and prednisolone. MR scan of the spinal cord showed bilateral cauda equina gadolinium enhancement and MR scan of the brain showed enhancing nodular hyperintensities in the internal capsule and globus pallidus. Cerebrospinal fluid (CSF) showed a pleocytosis with extremely low glucose, and positive DNA-PCR for Epstein-Barr virus. Her condition worsened despite empirically guided antimicrobial treatment. CSF immunophenotyping later identified mature, clonal B lymphocytes of large size, expressing CD19, CD20, CD200 antigens, and kappa light chain immunoglobulin, with absent CD5 and CD10 expression. We diagnosed a myeloradiculopathy from a monomorphic post-transplant lymphoproliferative disorder. This condition occurs after kidney transplantation and falls on the lymphoma spectrum. We review its clinical features, diagnosis and management.<\/jats:p>","DOI":"10.1136\/pn-2023-003696","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T13:20:28Z","timestamp":1683292828000},"page":"408-410","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Post-transplant lymphoproliferative disorder myeloradiculopathy"],"prefix":"10.1136","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-7460","authenticated-orcid":false,"given":"T\u00e1cio Luis Cavalcante","family":"Coradine","sequence":"first","affiliation":[{"name":"Departament of Neurology and Neurosurgery, General Neurology Unit, Universidade Federal de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas de Oliveira Cantaruti","family":"Guida","sequence":"additional","affiliation":[{"name":"Departament of Neurology and Neurosurgery, General Neurology Unit, Universidade Federal de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-8602","authenticated-orcid":false,"given":"Pedro","family":"Fraiman","sequence":"additional","affiliation":[{"name":"Departament of Neurology and Neurosurgery, General Neurology Unit, Universidade Federal de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrialdo Jos\u00e9","family":"Santos","sequence":"additional","affiliation":[{"name":"Departament of Neurology and Neurosurgery, Neuro-Oncology Unit, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luiz","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Departament of Neurology and Neurosurgery, General Neurology Unit, Universidade Federal de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando G P","family":"Barsottini","sequence":"additional","affiliation":[{"name":"Departament of Neurology and Neurosurgery, General Neurology Unit, Universidade Federal de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"2025090411362153000_23.5.408.1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1590\/0004-282x20170132","article-title":"Neurological complications of solid organ transplantation","volume":"75","author":"Pedroso","year":"2017","journal-title":"Arq Neuropsiquiatr"},{"key":"2025090411362153000_23.5.408.2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000347225","article-title":"Posttransplant lymphoproliferative disorder of the central nervous system","volume":"80","author":"Kempf","year":"2013","journal-title":"Pathobiology"},{"key":"2025090411362153000_23.5.408.3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4961"},{"key":"2025090411362153000_23.5.408.4","doi-asserted-by":"crossref","DOI":"10.1038\/s41394-018-0135-y","article-title":"Post-transplant lymphoproliferative disorder of the cauda equina in a kidney transplant recipient","volume":"4","author":"Nishiyama","year":"2018","journal-title":"Spinal Cord Ser Cases"},{"key":"2025090411362153000_23.5.408.5","doi-asserted-by":"crossref","DOI":"10.1186\/s13244-019-0726-6","article-title":"Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential","volume":"10","author":"White","year":"2019","journal-title":"Insights Imaging"},{"key":"2025090411362153000_23.5.408.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.12.130"},{"key":"2025090411362153000_23.5.408.7","doi-asserted-by":"crossref","unstructured":"Mortaz E , Tabarsi P , Mansouri D , et al . Cancers related to immunodeficiencies: update and perspectives. 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