{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:05:39Z","timestamp":1767985539012,"version":"3.49.0"},"reference-count":36,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2023,12,20]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Strachan\u2019s syndrome comprises a triad of optic, auditory and painful sensory peripheral neuropathy. It has been recognised since the late 19th century and is presumed to result from nutritional deficiency. Patients present acute or subacutely after a period of systemic illness, weight loss or, most commonly, dietary restriction, especially veganism, which can cause riboflavin (vitamin B<jats:sub>2<\/jats:sub>) and vitamin B<jats:sub>12<\/jats:sub> deficiencies. The syndrome is more common in people who are black British and often of Jamaican descent. We describe the clinical phenotype using a typical case example, review other endemic nutritional peripheral neuropathies and discuss the potential benefit of riboflavin as a treatment.<\/jats:p>","DOI":"10.1136\/pn-2023-003822","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T23:15:19Z","timestamp":1706656519000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Strachan\u2019s syndrome and riboflavin deficiency"],"prefix":"10.1136","volume":"24","author":[{"given":"Caroline","family":"Kramarz","sequence":"first","affiliation":[{"name":"Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"McHugh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4648-2896","authenticated-orcid":false,"given":"Alexander","family":"Rossor","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK"},{"name":"Department of Neurology, Guys and St Thomas\u2019 Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"2025090410335079000_24.2.121.1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/nutrit\/nuac043","article-title":"Riboflavin intake and status and relationship to anemia","volume":"81","author":"Aljaadi","year":"2022","journal-title":"Nutr Rev"},{"key":"2025090410335079000_24.2.121.2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9242-z"},{"key":"2025090410335079000_24.2.121.3","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12053"},{"key":"2025090410335079000_24.2.121.4","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0348"},{"key":"2025090410335079000_24.2.121.5","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.clineuro.2013.01.002","article-title":"Subacute peripheral and optic neuropathy syndrome with no evidence of a toxic or nutritional cause","volume":"115","author":"Allen","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"2025090410335079000_24.2.121.6","first-page":"139","article-title":"Malarial multiple peripheral neuritis","volume":"1","author":"Strachan","year":"1888","journal-title":"Sajou Ann Universal Med Sci"},{"key":"2025090410335079000_24.2.121.7","unstructured":"Strachan H . 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