{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:53:28Z","timestamp":1757613208955,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2024,9,5]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Alexia without agraphia is a neurological syndrome characterised by an acquired inability to read with a preserved ability to write. It is caused by the combined effect of two lesions: in the splenium of the corpus callosum and in the occipital lobe of the dominant hemisphere. Splenial lesions disconnect the language areas in the temporal and parietal lobes of the dominant hemisphere from the visual areas in the occipital cortex of the contralateral side, while lesions in the dominant occipital lobe cause homonymous hemianopia. We describe two patients with lesions affecting the splenium and dominant occipital lobe, with different causes. Together, these cases highlight the importance of performing a thorough language evaluation in patients presenting with homonymous visual field deficits, as otherwise, clinicians may overlook impairments in writing (agraphia) or reading (alexia).<\/jats:p>","DOI":"10.1136\/pn-2024-004235","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T13:20:17Z","timestamp":1727097617000},"page":"246-249","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Alexia without agraphia: from infarctions to malignancies"],"prefix":"10.1136","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-7298","authenticated-orcid":false,"given":"Ruben","family":"Jauregui","sequence":"first","affiliation":[{"name":"Department of Neurology, NYU Grossman School of Medicine, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5510-6656","authenticated-orcid":false,"given":"Julia","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Grossman School of Medicine, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Kuball","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Grossman School of Medicine, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dillan J","family":"Newbold","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Grossman School of Medicine, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riddhi","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Grossman School of Medicine, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Staudinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Grossman School of Medicine, New York, New York, USA"},{"name":"Department of Neurology, Veterans Affairs New York Harbor Healthcare System, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"2025090411383191000_25.3.246.1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412440596"},{"key":"2025090411383191000_25.3.246.2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00429-023-02624-z","article-title":"The angular gyrus serves as an interface between the non-lexical reading network and the semantic system: evidence from dynamic causal modeling","volume":"229","author":"Junker","year":"2024","journal-title":"Brain Struct Funct"},{"key":"2025090411383191000_25.3.246.3","article-title":"Alexia Without Agraphia: A Rare Entity","volume":"9","author":"Rupareliya","year":"2017","journal-title":"Cureus"},{"key":"2025090411383191000_25.3.246.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00596338"},{"key":"2025090411383191000_25.3.246.5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10072-016-2739-y","article-title":"Pure alexia in a patient with multiple sclerosis","volume":"38","author":"Potagas","year":"2017","journal-title":"Neurol Sci"},{"key":"2025090411383191000_25.3.246.6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.wneu.2015.12.071","article-title":"Glioblastoma Presenting with Pure Alexia and Palinopsia Involving the Left Inferior Occipital Gyrus and Visual Word Form Area Evaluated with Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Tractography","volume":"89","author":"Huang","year":"2016","journal-title":"World Neurosurg"},{"key":"2025090411383191000_25.3.246.7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11910-020-01069-9","article-title":"Gerstmann Syndrome","volume":"20","author":"Ardila","year":"2020","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2025090411383191000_25.3.246.8","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.2.151"},{"key":"2025090411383191000_25.3.246.9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.086983"},{"key":"2025090411383191000_25.3.246.10","doi-asserted-by":"crossref","DOI":"10.1212\/CPJ.0000000000200196","article-title":"Diffusion-Restricted Lesions of the Splenium: Clinical Presentation, Radiographic Patterns, and Patient Outcomes","volume":"13","author":"Stamm","year":"2023","journal-title":"Neurol Clin Pract"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/pn-2024-004235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T18:38:40Z","timestamp":1757011120000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/pn-2024-004235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,5,15]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/pn-2024-004235"],"URL":"https:\/\/doi.org\/10.1136\/pn-2024-004235","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"type":"print","value":"1474-7758"},{"type":"electronic","value":"1474-7766"}],"subject":[],"published":{"date-parts":[[2024,9,23]]}}}