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The diagnosis was confirmed at postmortem by immunohistochemistry of spinal and brain lesions. MRI showing CNS lesions consistent with demyelination is common and lymphoma is rarely the cause. However, when there is high clinical suspicion, tissue diagnosis should be sought whether by skin, lymph node or brain biopsy.<\/jats:p>","DOI":"10.1136\/pn-2025-004606","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T17:20:21Z","timestamp":1754414421000},"page":"254-257","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse large B-cell lymphoma masquerading as demyelination"],"prefix":"10.1136","volume":"26","author":[{"given":"Christopher","family":"Paisey","sequence":"first","affiliation":[{"name":"Southmead Hospital, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy","family":"Kaiyamo","sequence":"additional","affiliation":[{"name":"Southmead Hospital, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Lap","family":"Pang","sequence":"additional","affiliation":[{"name":"Radiology, Royal United Hospital Bath NHS Trust, Bath, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurjit","family":"Chohan","sequence":"additional","affiliation":[{"name":"Neurology, Royal United Hospital Bath NHS Trust, Bath, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"2026051402150813000_26.3.254.1","unstructured":"Padala SA , Kallam A . Diffuse large b-cell lymphoma. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2025."},{"key":"2026051402150813000_26.3.254.2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/bjh.14881","article-title":"Transformed Waldenstr\u00f6m macroglobulinaemia: clinical presentation and outcome. 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