{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:08:58Z","timestamp":1784034538934,"version":"3.55.0"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2025,11,3]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Long QT syndrome is an uncommon cardiac condition characterised by QT prolongation with a risk of syncope and sudden death from\n                    <jats:italic>torsades de pointes<\/jats:italic>\n                    ventricular arrhythmias. Seizures and seizure-like episodes can occur, and there may be a delay in recognising them as the underlying cause. A 37-year-old man who presented with a seemingly uncomplicated single seizure was later found to have long QT syndrome. His initial ECG showed a prolonged QTc (QT interval corrected for heart rate) of 507 ms (normal 350\u2013450), while subsequent \u2018interictal\u2019 ECGs were reportedly normal. We highlight the importance of considering long QT syndrome in first seizure (first fit) clinics by documenting the QTc interval and taking an appropriate family history.\n                  <\/jats:p>","DOI":"10.1136\/pn-2025-004748","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:20:25Z","timestamp":1764181225000},"page":"373-375","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Long QT syndrome causing an apparently typical first seizure"],"prefix":"10.1136","volume":"26","author":[{"given":"Jacob","family":"Biran","sequence":"first","affiliation":[{"name":"Clinical School, University of Cambridge School of Clinical Medicine, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Mellor","sequence":"additional","affiliation":[{"name":"Cardiology Department, Royal Papworth Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Saada","sequence":"additional","affiliation":[{"name":"Emergency Department, Addenbrooke\u2019s Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybil","family":"Stacpoole","sequence":"additional","affiliation":[{"name":"Department of Neurology, Peterborough City Hospital, Peterborough, England, UK"},{"name":"Department of Neurology, University of Cambridge School of Clinical Medicine, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-5963","authenticated-orcid":false,"given":"Kirsten Maurine","family":"Scott","sequence":"additional","affiliation":[{"name":"Neurology, Addenbrooke\u2019s Hospital Department of Neurology, Cambridge, UK"},{"name":"Department of Clinical Neurosciences, University of Cambridge John van Geest Centre for Brain Repair, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"2026071405250879000_26.4.373.1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5152\/akd.2015.5875","article-title":"QT interval variations and mortality risk: is there any relationship?","volume":"15","author":"Rezu\u015f","year":"2015","journal-title":"Anatol J Cardiol"},{"key":"2026071405250879000_26.4.373.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.863209"},{"key":"2026071405250879000_26.4.373.3","first-page":"739","article-title":"CONGENITAL LONG QT SYNDROME: A SYSTEMATIC REVIEW","volume":"60","author":"Gali\u0107","year":"2021","journal-title":"Acta Clin Croat"},{"key":"2026071405250879000_26.4.373.4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.211672"},{"key":"2026071405250879000_26.4.373.5","unstructured":"1-2-3-LQTS-Risk Calculator. 2025. Available: https:\/\/1-2-3-lqt.unipv.it"},{"key":"2026071405250879000_26.4.373.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.038"},{"key":"2026071405250879000_26.4.373.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.3.1136"},{"key":"2026071405250879000_26.4.373.8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0735-6757(92)90071-5","article-title":"Long QT syndrome presenting as a seizure","volume":"10","author":"Herman","year":"1992","journal-title":"Am J Emerg Med"},{"key":"2026071405250879000_26.4.373.9","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2018-001959"},{"key":"2026071405250879000_26.4.373.10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4103\/apc.apc_10_21","article-title":"Overt long QT syndrome in children presenting with seizure disorders in Pakistan","volume":"14","author":"Rashid","year":"2021","journal-title":"Ann Pediatr Cardiol"},{"key":"2026071405250879000_26.4.373.11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335760.02995.ca"},{"key":"2026071405250879000_26.4.373.12","unstructured":"National institute for health and care excellence (NICE) . Epilepsies in children, young people and adults (nice guideline 217). 2022. Available: https:\/\/www.nice.org.uk\/guidance\/ng217"},{"key":"2026071405250879000_26.4.373.13","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12872-021-02174-4","article-title":"Winning hearts and minds: ECG reporting in the first seizure clinic","volume":"21","author":"Huang","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"2026071405250879000_26.4.373.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.02.011"},{"key":"2026071405250879000_26.4.373.15","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad213","article-title":"Manual vs. automatic assessment of the QT-interval and corrected QT","volume":"25","author":"Neumann","year":"2023","journal-title":"Europace"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/pn-2025-004748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:25:18Z","timestamp":1784031918000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/pn-2025-004748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,14]]},"published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1136\/pn-2025-004748"],"URL":"https:\/\/doi.org\/10.1136\/pn-2025-004748","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"value":"1474-7758","type":"print"},{"value":"1474-7766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}