{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:14:15Z","timestamp":1790914455539,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2025,7,17]]},"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Adenopathy and an extensive skin patch overlying a plasmacytoma (AESOP) syndrome is a rare condition characterised by an erythemato-violaceous patch on the skin, accompanied by an underlying solitary plasmacytoma. It may give an early clue for the diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) syndrome, an uncommon multisystem disorder driven by plasma cell dyscrasia. We describe a 62-year-old man with sensorimotor peripheral neuropathy, unintentional weight loss and a persistent skin rash. Diagnostic findings, including elevated vascular endothelial growth factor, an immunoglobulin A kappa paraprotein and a skin\/sternal biopsy, led to the diagnosis of AESOP and POEMS syndrome. This case underscores the importance of early recognition of AESOP syndrome as a potential lifesaving clue for the early diagnosis of POEMS syndrome.<\/jats:p>","DOI":"10.1136\/pn-2025-004759","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T09:30:11Z","timestamp":1755163811000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["AESOP syndrome: a rare and early indicator of POEMS syndrome"],"prefix":"10.1136","volume":"26","author":[{"given":"Joumana","family":"Freiha","sequence":"first","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust Wessex Neurological Centre, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Lodwick","sequence":"additional","affiliation":[{"name":"Department of Haematology, Southampton University Hospitals NHS Trust, Southampton, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Roche","sequence":"additional","affiliation":[{"name":"Department of Pathology, Southampton University Hospitals NHS Trust, Southampton, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8245-0942","authenticated-orcid":false,"given":"Chinar","family":"Osman","sequence":"additional","affiliation":[{"name":"Neurosciences, Wessex Neurological Centre, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"2026031908251001000_26.1.63.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200301000-00005"},{"key":"2026031908251001000_26.1.63.2","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1001\/archdermatol.2012.2858","article-title":"A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma) in a Malignant Blue-Cell Tumor","volume":"148","author":"Foo","year":"2012","journal-title":"Arch Dermatol"},{"key":"2026031908251001000_26.1.63.3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.clindermatol.2020.10.002","article-title":"AESOP syndrome: a potential life-saving and early clue to the diagnosis of POEMS syndrome","volume":"39","author":"Lenormand","year":"2021","journal-title":"Clin Dermatol"},{"key":"2026031908251001000_26.1.63.4","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/cup.12798","article-title":"Skin manifestations of POEMS and AESOP syndrome in the same patient revealing plasma cell dyscrasia","volume":"43","author":"Rongioletti","year":"2016","journal-title":"J Cutan Pathol"},{"key":"2026031908251001000_26.1.63.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2299"},{"key":"2026031908251001000_26.1.63.6","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000796","article-title":"Comprehensive Diagnosis and Management of POEMS Syndrome","volume":"6","author":"D\u2019Sa","year":"2022","journal-title":"Hemasphere"},{"key":"2026031908251001000_26.1.63.7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000381302","article-title":"Cutaneous Manifestations in POEMS Syndrome: Case Report and Review","volume":"7","author":"Marinho","year":"2015","journal-title":"Case Rep Dermatol"},{"key":"2026031908251001000_26.1.63.8","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1365-4632.2012.05648.x","article-title":"Cutaneous manifestations in patients with POEMS syndrome","volume":"52","author":"Miest","year":"2013","journal-title":"Int J Dermatology"},{"key":"2026031908251001000_26.1.63.9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/cup.13514","article-title":"Adenopathy and extensive skin patch overlying a plasmacytoma with unusual histologic findings in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome and Castleman disease","volume":"46","author":"Dagrosa","year":"2019","journal-title":"J Cutan Pathol"},{"key":"2026031908251001000_26.1.63.10","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.amjmed.2012.03.004","article-title":"Skin Patch, Polyneuropathy, and Paraproteinemia","volume":"125","author":"N\u00e9el","year":"2012","journal-title":"Am J Med"}],"container-title":["Practical 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