{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:12:06Z","timestamp":1778753526015,"version":"3.51.4"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2025,9,22]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>We describe a rare cause of bilateral vision loss in a middle-aged man caused by leptomeningeal metastasis from an occult adenocarcinoma.<\/jats:p>","DOI":"10.1136\/pn-2025-004805","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T08:00:32Z","timestamp":1760515232000},"page":"251-253","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Focal leptomeningeal metastases causing binocular vision loss"],"prefix":"10.1136","volume":"26","author":[{"given":"Supriya","family":"Uppula","sequence":"first","affiliation":[{"name":"Neurology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapna","family":"Mittal","sequence":"additional","affiliation":[{"name":"Neurology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3370","authenticated-orcid":false,"given":"Divyani","family":"Garg","sequence":"additional","affiliation":[{"name":"Neurology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Garg","sequence":"additional","affiliation":[{"name":"Neuroradiology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantanu","family":"Bora","sequence":"additional","affiliation":[{"name":"Neurosurgery, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charli","family":"Roy","sequence":"additional","affiliation":[{"name":"Neuropathology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Mahalik","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khangembam Bangkim","family":"Chandra","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-7398","authenticated-orcid":false,"given":"Divya M","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Neurology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awadh K","family":"Pandit","sequence":"additional","affiliation":[{"name":"Neurology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achal Kumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Neurology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-1961","authenticated-orcid":false,"given":"Ayush","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Neurology, AIIMS, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"2026051402150816000_26.3.251.1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.21037\/apm-20-973","article-title":"An overview of leptomeningeal disease","volume":"10","author":"Nguyen","year":"2021","journal-title":"Ann Palliat Med"},{"key":"2026051402150816000_26.3.251.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.131"},{"key":"2026051402150816000_26.3.251.3","doi-asserted-by":"publisher","DOI":"10.2174\/157339411797642597"},{"key":"2026051402150816000_26.3.251.4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s11912-023-01432-2","article-title":"Diagnostic and Therapeutic Updates in Leptomeningeal Disease","volume":"25","author":"Roy-O\u2019Reilly","year":"2023","journal-title":"Curr Oncol Rep"},{"key":"2026051402150816000_26.3.251.5","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20272"},{"key":"2026051402150816000_26.3.251.6","doi-asserted-by":"publisher","DOI":"10.1136\/pn-2024-004167"},{"key":"2026051402150816000_26.3.251.7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jocn.2017.01.024","article-title":"Leptomeningeal metastases presenting exclusively with ocular disturbance in 34 patients: A tertiary care cancer hospital experience","volume":"39","author":"Mayer","year":"2017","journal-title":"J Clin Neurosci"},{"key":"2026051402150816000_26.3.251.8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/tjo.tjo_107_17","article-title":"Blindness due to leptomeningeal carcinomatosis as an initial manifestation of recurrent acute lymphoblastic leukemia","volume":"9","author":"Huang","year":"2019","journal-title":"Taiwan J Ophthalmol"},{"key":"2026051402150816000_26.3.251.9","doi-asserted-by":"crossref","first-page":"101748","DOI":"10.1016\/j.ajoc.2022.101748","article-title":"Visual loss as the initial manifestation of an ignored disseminated prostate cancer: A case report","volume":"28","author":"Miranda","year":"2022","journal-title":"Am J Ophthalmol Case Rep"},{"key":"2026051402150816000_26.3.251.10","first-page":"3614225","article-title":"Sudden Vision Loss Secondary to Optic Nerve Infiltration as a Presenting Symptom of Metastatic Lung Adenocarcinoma","volume":"2022","author":"Shamim","year":"2022","journal-title":"Case Rep Ophthalmol Med"},{"key":"2026051402150816000_26.3.251.11","doi-asserted-by":"crossref","first-page":"892523","DOI":"10.1155\/2013\/892523","article-title":"Optic neuritis as isolated manifestation of leptomeningeal carcinomatosis: a case report and systematic review of ocular manifestations of neoplastic meningitis","volume":"2013","author":"Lanfranconi","year":"2013","journal-title":"Neurol Res Int"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/pn-2025-004805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:16:10Z","timestamp":1778750170000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/pn-2025-004805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,5,14]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/pn-2025-004805"],"URL":"https:\/\/doi.org\/10.1136\/pn-2025-004805","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"value":"1474-7758","type":"print"},{"value":"1474-7766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]}}}