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Although there are potential confounding factors, the combination of the clinical presentation, deranged liver function tests, resolution following the diagnostic lumbar puncture, starting acetazolamide and stopping the supplements supported a diagnosis of vitamin A-induced intracranial hypertension. With the rising global use of dietary supplements, clinicians should routinely enquire about over-the-counter products in people with unexplained intracranial hypertension to reduce avoidable investigations, prolonged treatments and risk of visual morbidity.<\/jats:p>","DOI":"10.1136\/pn-2025-004874","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:20:48Z","timestamp":1777396848000},"page":"pn-2025-004874","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Intracranial hypertension: the hidden risk of supplements containing vitamin A"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0946-5377","authenticated-orcid":false,"given":"Mitchell Harry","family":"Dennis","sequence":"first","affiliation":[{"name":"Neurology and Acute Stroke Unit, James Cook University Hospital, Middlesbrough, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Goldring","sequence":"additional","affiliation":[{"name":"Neurology, James Cook University Hospital, Middlesbrough, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Frederick","family":"Chapman","sequence":"additional","affiliation":[{"name":"Neurology, James Cook University Hospital, Middlesbrough, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"2026042810202008000_pn-2025-004874v1.1","unstructured":"MyProtein . Multivitamins for men [internet]. Available: https:\/\/www.myprotein.com\/p\/sports-nutrition\/multivitamins-for-men\/10530421\/ [Accessed 23 Aug 2025]."},{"key":"2026042810202008000_pn-2025-004874v1.2","doi-asserted-by":"publisher","DOI":"10.1159\/000114758"},{"key":"2026042810202008000_pn-2025-004874v1.3","unstructured":"Horowitz BZ . Did hypervitaminosis A have a role in Mawson\u2019s ill-fated Antarctic exploration? Clin Toxicol 2022;1\u20135."},{"key":"2026042810202008000_pn-2025-004874v1.4","doi-asserted-by":"crossref","unstructured":"Grzybowski DM , Katz SE , Criden MR , et al . The role of vitamin A and its CSF metabolites in supporting a novel mechanism of idiopathic intracranial hypertension. Fluids Barriers CNS 2007;4. doi:10.1186\/1743-8454-4-S1-S44","DOI":"10.1186\/1743-8454-4-S1-S44"},{"key":"2026042810202008000_pn-2025-004874v1.5","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31815b9af0"},{"key":"2026042810202008000_pn-2025-004874v1.6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jns.2016.11.014","article-title":"Role of vitamin A metabolism in IIH: results from the idiopathic intracranial hypertension treatment trial","volume":"372","author":"Libien","year":"2017","journal-title":"J Neurol Sci"},{"key":"2026042810202008000_pn-2025-004874v1.7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/WNO.0000000000002236","article-title":"Drug-induced intracranial hypertension: the adverse effects of acne medications and topical retinoids","volume":"45","author":"Shaia","year":"2025","journal-title":"J Neuroophthalmol"},{"key":"2026042810202008000_pn-2025-004874v1.8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/01658107.2017.1367931","article-title":"Pseudotumor cerebri syndrome with resolution after discontinuing high vitamin A-containing dietary supplement: case report and review","volume":"42","author":"Chisholm","year":"2018","journal-title":"Neuroophthalmology"},{"key":"2026042810202008000_pn-2025-004874v1.9","article-title":"A rare case report of benign intracranial hypertension caused by hypervitaminosis A","volume":"16","author":"Hajaj","year":"2024","journal-title":"Cureus"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/pn-2025-004874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:20:51Z","timestamp":1777396851000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/pn-2025-004874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":9,"alternative-id":["10.1136\/pn-2025-004874"],"URL":"https:\/\/doi.org\/10.1136\/pn-2025-004874","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"value":"1474-7758","type":"print"},{"value":"1474-7766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}