{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:02:41Z","timestamp":1793793761895,"version":"4.6.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1039","license":[{"start":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T00:00:00Z","timestamp":1327104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pulmonary arterial hypertension (PAH) is an uncommon condition associated with significant morbidity and mortality. It has diverse aetiology with differing clinical presentations, imaging features and treatments that range from surgical treatment of proximal chronic thromboembolic disease to targeted medical therapies in small vessel disease. Current classification of pulmonary hypertension (PH) is clinically based and groups diseases with similar pathophysiological mechanisms and therapeutic approaches. Groupings include conditions characterised by diffuse small vessel diseases such as idiopathic PAH, PH secondary to chronic hypoxic lung disease, left sided cardiac disease, chronic large vessel obstruction such as chronic thromboembolic disease and a miscellaneous group of diseases. The physiological manifestation of all of these diseases is increased pulmonary vascular resistance and PAH and while clinical features may provide a clue to diagnosis imaging plays a fundamental role in establishing a precise diagnosis and therefore guides therapy. A broad range of imaging modalities is available for the patient with suspected PH including chest radiograph, echocardiography, ventilation\/perfusion scintigraphy, catheter pulmonary angiography as well as cross-sectional CT and MRI. Each modality has its strengths and limitations and different techniques may be used at different stages of diagnostic investigation and frequently complement each other. For example, while MRI and echocardiography permit cardiac structural and functional assessment, CT pulmonary angiography provides exquisite morphological information about the proximal pulmonary vasculature and lung parenchyma but little functional information. Modern cross-sectional imaging techniques (CT and MRI) hold the promise of a comprehensive evaluation of the heart, circulation and lung parenchyma in PH. The authors present a multimodality-imaging algorithm for the investigation of patients with suspected PH though it is acknowledged that there is some variation in practice depending on availability of resources and expertise.<\/jats:p>","DOI":"10.1136\/postgradmedj-2011-130292","type":"journal-article","created":{"date-parts":[[2012,1,22]],"date-time":"2012-01-22T01:19:42Z","timestamp":1327195182000},"page":"271-279","source":"Crossref","is-referenced-by-count":30,"title":["Imaging in pulmonary hypertension, part 1: clinical perspectives, classification, imaging techniques and imaging algorithm"],"prefix":"10.1093","volume":"88","author":[{"given":"Caroline","family":"McCann","sequence":"first","affiliation":[{"name":"Department of Radiology, Papworth Hospital , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Gopalan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Papworth Hospital , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sheares","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Diseases Unit, Papworth Hospital , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Screaton","sequence":"additional","affiliation":[{"name":"Department of Radiology, Papworth Hospital , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,21]]},"reference":[{"key":"2023041906381209700_bib1","volume-title":"Primary Pulmonary Hypertension","author":"Hatano","year":"1975"},{"key":"2023041906381209700_bib2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1183\/09031936.00145608","article-title":"Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review","volume":"34","author":"Kovacs","year":"2009","journal-title":"Eur Respir J"},{"key":"2023041906381209700_bib3","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.jacc.2009.04.011","article-title":"Diagnosis and assessment of pulmonary hypertension","volume":"54","author":"Badesch","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2023041906381209700_bib4","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1152\/jappl.1993.74.4.1666","article-title":"Mechanisms of improved arterial oxygenation after peripheral chemoreceptor stimulation during hypoxic exercise","volume":"74","author":"Naeije","year":"1993","journal-title":"J Appl Physiol"},{"key":"2023041906381209700_bib5","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1183\/09031936.00139009","article-title":"Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"34","author":"Galie","year":"2009","journal-title":"Eur Respir J"},{"key":"2023041906381209700_bib6","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/bmj.326.7394.835","article-title":"Treatment of pulmonary hypertension","volume":"326","author":"Peacock","year":"2003","journal-title":"BMJ"},{"key":"2023041906381209700_bib7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertension. 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