{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:18:12Z","timestamp":1715591892578},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1042","license":[{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cardiac troponins are measured in acute coronary syndrome (ACS) and other conditions. The authors investigate the prognostic significance of cardiac troponin T (TnT) test and comorbid medical conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive patients admitted to the Aintree University Hospital, Liverpool, between 2 January 2004 and 29 February 2004 who had TnT measurement were included. Patients were separated into normal (&amp;lt;0.01\u2005\u03bcg\/l) or raised TnT levels (\u22650.01\u2005\u03bcg\/l), and further categorised into: (1) normal TnT with unstable angina; (2) normal TnT with non-ACS; (3) raised TnT with ACS; and (4) raised TnT with non-ACS. Cox regression was used to identify prognostic variables, and logrank test to compare 7-year survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 1021 patients, 313 had raised TnT (195 ACS, 118 non-ACS) and 708 normal TnT (80 ACS, 628 non-ACS). Age (HR 1.06; 95% CI 1.05 to 1.07), congestive cardiac failure (HR 1.37; 95% CI 1.11 to 1.69), cerebrovascular disease (HR 1.37; 95% CI 1.10 to 1.71), chronic obstructive airway disease (HR 1.44; 95% CI 1.19 to 1.75), liver disease (HR 4.16; 95% CI 2.37 to 7.31), renal disease (HR 1.83; 95% CI 1.27 to 2.64), tumour (HR 1.39; 95% CI 1.07 to 1.79), lymphoma (HR 4.81; 95% CI 2.07 to 11.16), metastatic cancer (HR 3.55; 95% CI 2.32 to 5.45) and a higher Charlson's comorbidity score (HR 1.20, 95% CI 1.13 to 1.26) were adverse predictors. Both raised TnT with ACS (HR 1.92, 95% CI 1.54 to 2.39) and raised TnT with non-ACS (HR 2.37, 95% CI 1.87 to 3.00) were associated with worse survival. Raised TnT with non-ACS had a worse survival than raised TnT with ACS (p=0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Hospitalised patients with raised TnT levels from any cause predicted a higher mortality than normal TnT, with worst survival in those without an obvious ACS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/postgradmedj-2011-130466","type":"journal-article","created":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T02:12:28Z","timestamp":1335579148000},"page":"437-442","source":"Crossref","is-referenced-by-count":6,"title":["Early and late mortality in hospitalised patients with raised cardiac troponin T"],"prefix":"10.1093","volume":"88","author":[{"given":"Peter Sze Chai","family":"Wong","sequence":"first","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Dawn","family":"Jones","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Ashrafi","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Khanzada","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upul","family":"Wickramarachchi","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Touran Heidi","family":"Keen","sequence":"additional","affiliation":[{"name":"Aintree Cardiac Centre, University Hospital Aintree , Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek Richard","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Mathematics, School of Mathematical and Physical Sciences, University of Sussex , Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,4,27]]},"reference":[{"key":"2023041906571614000_bib1","first-page":"e148","article-title":"ACC\/AHA 2007 guidelines for the management of patients with unstable angina\/non\u2013ST-elevation myocardial infarction: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients with Unstable Angina\/Non\u2013ST-Elevation Myocardial Infarction)","volume":"116","author":"Anderson","year":"2007","journal-title":"Circulation"},{"key":"2023041906571614000_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCULATIONAHA.107.188209","article-title":"2007 Focused Update of the ACC\/AHA 2004 Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Group to Review New Evidence and Update the ACC\/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction)","volume":"117","author":"Antman","year":"2008","journal-title":"Circulation"},{"key":"2023041906571614000_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/hrt.2010.195511","article-title":"Quantitative troponin and death, cardiogenic shock, cardiac arrest and new heart failure in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS): insights from the Global Registry of Acute Coronary Events","volume":"97","author":"Jolly","year":"2011","journal-title":"Heart"},{"key":"2023041906571614000_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ahj.2010.10.004","article-title":"Risk adjustment for in-hospital mortality of contemporary patients with acute myocardial infarction: the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry\u00ae - 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