{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:10:45Z","timestamp":1692691845821},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"1099","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Severe calcific aortic stenosis is relatively common, and unless treated with valve replacement it carries an adverse prognosis. A large number of patients, however, are denied surgery due to their advanced age or coexistent medical conditions that increase perioperative cardiovascular risks. Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, is a new therapeutic modality for treatment of older patients with severe symptomatic aortic stenosis and other comorbidities, who have an inherently high surgical risk. This review will provide an overview of the pivotal trials in the development of TAVI; while also investigating important complications and limitations of the procedure and evaluating how new valves are being designed and clinically evaluated, with the ultimate goal of reducing potential complications and expanding the use of TAVI to lower-risk patient cohorts.<\/jats:p>","DOI":"10.1136\/postgradmedj-2016-134554","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T02:11:32Z","timestamp":1484878292000},"page":"280-288","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Transcatheter aortic valve implantation: new hope in the management of valvular heart disease"],"prefix":"10.1093","volume":"93","author":[{"given":"Sofia","family":"Metaxa","sequence":"first","affiliation":[{"name":"Frimley Health NHS Foundation Trust , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Royal Free Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantinos G","family":"Missouris","sequence":"additional","affiliation":[{"name":"Frimley Health NHS Foundation Trust , London, UK"},{"name":"University of Cyprus Medical School , Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/0735-1097(93)90249-Z","article-title":"Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample","volume":"21","author":"Lindroos","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.38.1S5.V-61","article-title":"Aortic stenosis","volume":"38","author":"Ross","year":"1968","journal-title":"Circulation"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0002-8703(79)90465-4","article-title":"Rate of progression of severity of valvular aortic stenosis in the adult","volume":"98","author":"Cheitlin","year":"1979","journal-title":"Am Heart J"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.athoracsur.2009.05.056","article-title":"The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2\u2014isolated valve surgery","volume":"88","author":"O'Brien","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1136\/hrt.82.2.143","article-title":"To operate or not on elderly patients with aortic stenosis: the decision and its consequences","volume":"82","author":"Bouma","year":"1999","journal-title":"Heart"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.jacc.2007.08.011","article-title":"Unoperated patients with severe aortic stenosis","volume":"50","author":"Bach","year":"2007","journal-title":"J Am Coll Cadiol"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0140-6736(86)90716-6","article-title":"Percutaneous transluminal valvuloplasty of acquired aortic stenosis in elderly patients: an alternative to valve replacement?","volume":"1","author":"Cribier","year":"1986","journal-title":"Lancet"},{"key":"2023041308191015400_","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/oxfordjournals.eurheartj.a060238","article-title":"Transluminal implantation of artificial heart valves. 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