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There is an over-reliance on a biological marker of the condition, the multiple sleep latency test (MSLT), which, like many tests, has a significant false-positive and false-negative rate. This review aims to discuss some of the difficulties in achieving a diagnosis, interpretation of investigations, differential diagnosis, and appropriate management of patients with narcolepsy.<\/jats:p>","DOI":"10.1136\/practneurol-2014-000837","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T23:19:49Z","timestamp":1400195989000},"page":"323-331","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Narcolepsy: a clinical review"],"prefix":"10.1136","volume":"14","author":[{"given":"Guy","family":"Leschziner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"2025090410072591000_14.5.323.1","first-page":"320","article-title":"Criteria for the diagnosis of the narcoleptic syndrome","volume":"32","author":"Yoss","year":"1957","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"2025090410072591000_14.5.323.2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1960.01710040091011"},{"key":"2025090410072591000_14.5.323.3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.2_Suppl_1.S16"},{"key":"2025090410072591000_14.5.323.4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22587"},{"key":"2025090410072591000_14.5.323.5","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","author":"Aran","year":"2009","journal-title":"Sleep"},{"key":"2025090410072591000_14.5.323.6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41366"},{"key":"2025090410072591000_14.5.323.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81965-0"},{"key":"2025090410072591000_14.5.323.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00058-1"},{"key":"2025090410072591000_14.5.323.9","doi-asserted-by":"publisher","DOI":"10.1038\/79690"},{"key":"2025090410072591000_14.5.323.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.08.002"},{"key":"2025090410072591000_14.5.323.11","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.2029"},{"key":"2025090410072591000_14.5.323.12","unstructured":"International Classification of Sleep Disorders. 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