{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:02:24Z","timestamp":1783735344021,"version":"3.55.0"},"reference-count":12,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2015,10,12]]},"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>\n                  <jats:italic>Capnocytophaga canimorsus<\/jats:italic> is a common Gram-negative anaerobic bacterium from the oral flora of dogs, typically transmitted to humans by dog bites. We report a case of <jats:italic>C. canimorsus<\/jats:italic> meningitis where there was (on presentation) no apparent predisposing risk factor and in whom we used 16S rRNA PCR gene sequencing to identify the pathogen quickly and to switch to appropriate antibiotic therapy. Physicians should be aware of potential <jats:italic>C. canimorsus<\/jats:italic> meningitis if conventional cerebrospinal fluid bacterial culture is negative but Gram staining identifies bacteria, especially in patients with a recent dog bite or known immunodeficiency.<\/jats:p>","DOI":"10.1136\/practneurol-2015-001166","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T22:39:40Z","timestamp":1448491180000},"page":"136-138","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["<i>Capnocytophaga canimorsus<\/i> meningitis diagnosed by 16S rRNA PCR"],"prefix":"10.1136","volume":"16","author":[{"given":"T M J","family":"Beernink","sequence":"first","affiliation":[{"name":"Department of Neurology, Bernhoven Hospital, Uden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Wever","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, \u2018s-Hertogenbosch, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H A","family":"Hermans","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Diagnostics, Jeroen Bosch Hospital, \u2018s-Hertogenbosch, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G T","family":"Bartholomeus","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bernhoven Hospital, Uden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"2025090409194640000_16.2.136.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-1-1"},{"key":"2025090409194640000_16.2.136.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00144007"},{"key":"2025090409194640000_16.2.136.3","unstructured":"Petti CA , Bosshard PP , Brandt ME , et al . Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; approved guidelines. CLSI document MM18-A. Wayne, PA: Clinical and Laboratory Standards Institute, 2008."},{"key":"2025090409194640000_16.2.136.4","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05853-11"},{"key":"2025090409194640000_16.2.136.5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/65.4.564"},{"key":"2025090409194640000_16.2.136.6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1128\/jcm.27.2.231-235.1989","article-title":"Capnocytophaga canimorsus sp. nov. (formerly CDC group DF-2), a cause of septicemia following dog bite, and C. cynodegmi sp. nov., a cause of localized wound infection following dog bite","volume":"27","author":"Brenner","year":"1989","journal-title":"J Clin Microbiol"},{"key":"2025090409194640000_16.2.136.7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6666.116-b"},{"key":"2025090409194640000_16.2.136.8","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.1.71"},{"key":"2025090409194640000_16.2.136.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.02.010"},{"key":"2025090409194640000_16.2.136.10","doi-asserted-by":"publisher","DOI":"10.1086\/345477"},{"key":"2025090409194640000_16.2.136.11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2001.00215.x"},{"key":"2025090409194640000_16.2.136.12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir692"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/practneurol-2015-001166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T16:19:52Z","timestamp":1757002792000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/practneurol-2015-001166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,25]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,3,15]]},"published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1136\/practneurol-2015-001166"],"URL":"https:\/\/doi.org\/10.1136\/practneurol-2015-001166","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"value":"1474-7758","type":"print"},{"value":"1474-7766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,25]]}}}