{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:20:32Z","timestamp":1760955632412,"version":"3.44.0"},"reference-count":2,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2016,2,14]]},"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>A 51-year-old man gave a 2-year history of worsening mobility, cognitive decline and headaches. He had a history of thromboembolic stroke, recurrent transient ischaemic attacks and a spontaneous intraventricular haemorrhage. On examination, he had livedo reticularis and perniosis and a systolic murmur. Catheter cerebral angiography showed peripheral small-vessel and medium-vessel vasculopathy resulting in pruning of the distal cortical vessels and tortuous irregular distal collaterals. Skin biopsy showed subtle vasculopathy with ectasia of capillaries and postcapillary venules but no frank vasculitis or arterial thrombosis. Repeated serum antiphospholipid antibody titres were negative. The clinical features, skin biopsy and angiogram findings strongly supported a diagnosis of Sneddon's syndrome. Clinicians should consider Sneddon's syndrome in patients with livedo reticularis and stroke. There are treatment dilemmas in this situation when ischaemic and haemorrhagic cerebral events coexist.<\/jats:p>","DOI":"10.1136\/practneurol-2015-001341","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T23:19:10Z","timestamp":1457738350000},"page":"300-303","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Sneddon's syndrome: it is all in the ectoderm"],"prefix":"10.1136","volume":"16","author":[{"given":"Zoe","family":"Rutter-Locher","sequence":"first","affiliation":[{"name":"Department of Neurology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Neurology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Creamer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Neurology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopen","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Haematology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Nashef","sequence":"additional","affiliation":[{"name":"Department of Neurology, King's College Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"2025090411120621000_16.4.300.1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1186\/s13023-014-0215-4","article-title":"Sneddon inverted question marks syndrome: a comprehensive review of the literature","volume":"9","author":"Wu","year":"2014","journal-title":"Orphanet J Rare Dis"},{"key":"2025090411120621000_16.4.300.2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199907000-00001"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/practneurol-2015-001341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T18:20:20Z","timestamp":1757010020000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/practneurol-2015-001341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":2,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,7,14]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1136\/practneurol-2015-001341"],"URL":"https:\/\/doi.org\/10.1136\/practneurol-2015-001341","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"type":"print","value":"1474-7758"},{"type":"electronic","value":"1474-7766"}],"subject":[],"published":{"date-parts":[[2016,3,11]]}}}