{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:54:59Z","timestamp":1782258899683,"version":"3.54.5"},"reference-count":4,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2016,9,12]]},"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Adams and Foley described asterixis in the 1940s in patients with hepatic encephalopathy, but it has since been associated with a wide range of potential causes, both in neurology and general medicine. Here, we review the history, characteristics and clinical significance of this important clinical sign.<\/jats:p>","DOI":"10.1136\/practneurol-2016-001393","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T21:34:21Z","timestamp":1478122461000},"page":"60-62","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Asterixis"],"prefix":"10.1136","volume":"17","author":[{"given":"Mark A","family":"Ellul","sequence":"first","affiliation":[{"name":"Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK"},{"name":"Institute of Infection and Global Health, University of Liverpool, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Royal Liverpool University Hospital, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Larner","sequence":"additional","affiliation":[{"name":"Cognitive Function Clinic, The Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"2025090410004556000_17.1.60.1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/oso\/9780195379082.005.0010","volume-title":"Raymond Adams: a life of mind and muscle","volume":"177","author":"Laureno","year":"2009"},{"key":"2025090410004556000_17.1.60.2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s11011-014-9514-7","article-title":"Asterixis: a study of 103 patients","volume":"29","author":"Pal","year":"2014","journal-title":"Metab Brain Dis"},{"key":"2025090410004556000_17.1.60.3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/ane.12217","article-title":"Cortical activation associated with asterixis in manifest hepatic encephalopathy","volume":"130","author":"Butz","year":"2014","journal-title":"Acta Neurol Scand"},{"key":"2025090410004556000_17.1.60.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4187"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/practneurol-2016-001393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T17:00:54Z","timestamp":1757005254000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/practneurol-2016-001393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,2]]},"references-count":4,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,17]]},"published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1136\/practneurol-2016-001393"],"URL":"https:\/\/doi.org\/10.1136\/practneurol-2016-001393","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"value":"1474-7758","type":"print"},{"value":"1474-7766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,2]]}}}