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There are several possible pathophysiologic mechanisms including hypovolaemia, small-fibre peripheral neuropathy and hyperadrenergic states. POTS can also be associated with several disorders including mastocytosis, Ehlers-Danlos syndrome (hypermobility type) and autoimmune disorders. The treatment is focused on symptom relief and not solely on reducing tachycardia. Given its varying presentations, it is important to employ a practical, mechanism-focused approach to the diagnosis and management of POTS.<\/jats:p>","DOI":"10.1136\/practneurol-2016-001405","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T22:29:10Z","timestamp":1474583350000},"page":"431-438","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical challenges in the diagnosis and management of postural tachycardia syndrome"],"prefix":"10.1136","volume":"16","author":[{"given":"Pearl K","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Neurology, UT Health Science Center San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3799-6847","authenticated-orcid":false,"given":"Brett H","family":"Shaw","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, 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