{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:44:45Z","timestamp":1790775885254,"version":"4.1.0"},"reference-count":3,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2016,8,17]]},"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Radiotherapy is the mainstay of treatment after surgery for high-grade gliomas and is usually well tolerated. Radiation toxicity in the brain is usually classified according to the timing of side effects in relation to treatment, as either <jats:italic>acute<\/jats:italic> (during radiotherapy), <jats:italic>early delayed<\/jats:italic> (within 12\u2005weeks of radiotherapy) or <jats:italic>late delayed<\/jats:italic> (months to years after radiotherapy). We report two cases of young women who developed severe acute demyelination within 4\u2005months of radiotherapy for glioma, one of whom had a previous history of transverse myelitis. Both improved with corticosteroids and remain in tumour remission. These cases emphasise the importance of careful discussion with patients before starting radiotherapy if there is a previous history of central nervous system demyelination or multiple white matter lesions on MRI.<\/jats:p>","DOI":"10.1136\/practneurol-2016-001432","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T22:14:37Z","timestamp":1473459277000},"page":"35-38","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Acute demyelination following radiotherapy for glioma: a cautionary tale"],"prefix":"10.1136","volume":"17","author":[{"given":"Marina","family":"Milic","sequence":"first","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy H","family":"Rees","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"2025090410570868000_17.1.35.1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-61-731-1043"},{"key":"2025090410570868000_17.1.35.2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197910)44:4<1256::AID-CNCR2820440415>3.0.CO;2-T"},{"key":"2025090410570868000_17.1.35.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.014"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/practneurol-2016-001432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T17:58:00Z","timestamp":1757008680000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/practneurol-2016-001432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,9]]},"references-count":3,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,17]]},"published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1136\/practneurol-2016-001432"],"URL":"https:\/\/doi.org\/10.1136\/practneurol-2016-001432","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"value":"1474-7758","type":"print"},{"value":"1474-7766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,9]]}}}