{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:47:36Z","timestamp":1785466056674,"version":"3.56.0"},"reference-count":19,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2017,3,12]]},"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Withdrawing invasive ventilation from a person with motor neurone disease who lacks the relevant mental capacity raises ethical issues such as the withdrawal of life-sustaining treatment and establishing best interests. There is little available information on providing optimal symptom management to these patients during the withdrawal process. We describe a man with motor neurone disease who also had total locked-in syndrome at the time of ventilation withdrawal, and we document the legal, ethical, emotional and symptom control issues encountered in supporting him.<\/jats:p>","DOI":"10.1136\/practneurol-2016-001574","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T20:50:17Z","timestamp":1492721417000},"page":"383-386","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Withdrawal of invasive ventilation in a patient with motor neurone disease and total locked-in syndrome"],"prefix":"10.1136","volume":"17","author":[{"given":"Aoife","family":"Gleeson","sequence":"first","affiliation":[{"name":"Department of Palliative Medicine, Aneurin Bevan University Health Board, Gwent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faye","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Aneurin Bevan University Health Board, Gwent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"2025090411184849000_17.5.383.1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/154596830001400206","article-title":"Long-term tracheostomy ventilation in neuromuscular diseases: patient acceptance and quality of life","volume":"14","author":"Narayanaswami","year":"2000","journal-title":"Neurorehabil Neural Repair"},{"key":"2025090411184849000_17.5.383.2","doi-asserted-by":"publisher","DOI":"10.1177\/0269216310389224"},{"key":"2025090411184849000_17.5.383.3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.193631"},{"key":"2025090411184849000_17.5.383.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(03)00323-3"},{"issue":"Suppl 4","key":"2025090411184849000_17.5.383.5","first-page":"iv32","article-title":"The management of motor neurone disease","volume":"74","author":"Leigh","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025090411184849000_17.5.383.6","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050273"},{"key":"2025090411184849000_17.5.383.7","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2011.0133"},{"key":"2025090411184849000_17.5.383.8","unstructured":"Association for Palliative Medicine. 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