{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:53:09Z","timestamp":1757613189172,"version":"3.44.0"},"reference-count":35,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2017,7,2]]},"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Tuberculous meningitis presents a diagnostic and therapeutic challenge, and considering its long history and increasing global incidence, the evidence base for its treatment is relatively scanty. Many UK neurologists will have little first-hand experience of this deadly condition, and if faced with a patient with possible tuberculous meningitis will find decision making less than straightforward. In parts of East London (UK) the rates of tuberculosis and tuberculous meningitis are among the highest in Western Europe, and so the neurologists and respiratory physicians at the Royal London Hospital have encountered many such patients over the years. We have found experience to be a valuable teacher and so would like to share five cases that illustrate the complexities of diagnosis and management of the disease, and complications of its treatment.<\/jats:p>","DOI":"10.1136\/practneurol-2017-001653","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T20:40:24Z","timestamp":1503002424000},"page":"429-438","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Tuberculous tales: an East London experience"],"prefix":"10.1136","volume":"17","author":[{"given":"Apeksha M","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Neurology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Raciborska","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmilee","family":"Gnanapavan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica L C","family":"White","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"2025090410402302000_17.6.429.1","unstructured":"Public Health England. 2016. 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Automated Real-Time Nucleic Acid Amplification Technology for Rapid and Simultaneous Detection of Tuberculosis and Rifampicin Resistance: Xpert MTB\/RIF Assay for the Diagnosis of Pulmonary and Extrapulmonary TB in Adults and Children. Policy Update. 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