{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:29:59Z","timestamp":1768289399217,"version":"3.49.0"},"reference-count":6,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2018,1,14]]},"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis is a newly described, possibly under-recognised, severe inflammatory condition of the nervous system. The clinical presentation is variable but most commonly is a combination of meningitis, encephalitis and myelitis; other manifestations may include seizures, psychiatric symptoms and tremor. There is a significant association with malignancies, often occult, and with other autoimmune conditions. Although the disease responds well to corticosteroids acutely, it typically relapses when these are tapered, and so patients need long-term immunosuppression. We report a young man presenting with subacute meningoencephalitis and subsequent myelitis, and discuss the typical presentation and management of this severe but treatable condition.<\/jats:p>","DOI":"10.1136\/practneurol-2017-001863","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T11:13:46Z","timestamp":1518434026000},"page":"315-319","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-072X","authenticated-orcid":false,"given":"Angeliki","family":"Zarkali","sequence":"first","affiliation":[{"name":"East Kent Neurology Unit, East Kent University Hospitals NHS Foundation Trust, Canterbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Cousins","sequence":"additional","affiliation":[{"name":"East Kent Neurology Unit, East Kent University Hospitals NHS Foundation Trust, Canterbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilan","family":"Athauda","sequence":"additional","affiliation":[{"name":"East Kent Neurology Unit, East Kent University Hospitals NHS Foundation Trust, Canterbury, UK"},{"name":"University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Moses","sequence":"additional","affiliation":[{"name":"East Kent Microbiology and Virology, East Kent University Hospitals NHS Foundation Trust, Canterbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Moran","sequence":"additional","affiliation":[{"name":"East Kent Neurology Unit, East Kent University Hospitals NHS Foundation Trust, Canterbury, UK"},{"name":"King\u2019s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreedharan","family":"Harikrishnan","sequence":"additional","affiliation":[{"name":"East Kent Neurology Unit, East Kent University Hospitals NHS Foundation Trust, Canterbury, UK"},{"name":"King\u2019s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"2025090411420907000_18.4.315.1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1001\/jamaneurol.2016.2549","article-title":"Autoimmune glial fibrillary acidic protein astrocytopathy: a novel meningoencephalomyelitis","volume":"73","author":"Fang","year":"2016","journal-title":"JAMA Neurol"},{"key":"2025090411420907000_18.4.315.2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007677003387"},{"key":"2025090411420907000_18.4.315.3","doi-asserted-by":"crossref","unstructured":"Iorio R , Damato V , Evoli A , et al . Clinical and immunological characteristics of the spectrum of GFAP autoimmunity: a case series of 22 patients. 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