{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:06:35Z","timestamp":1793329595703,"version":"4.5.0"},"reference-count":28,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106359"],"award-info":[{"award-number":["106359"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Pract Neurol"],"accepted":{"date-parts":[[2018,8,21]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Rhabdomyolysis is the combination of symptoms (myalgia, weakness and muscle swelling) and a substantial rise in serum creatine kinase (CK) &gt;50\u2009000 IU\/L; there are many causes, but here we specifically address exertional rhabdomyolysis. The consequences of this condition can be severe, including acute kidney injury and requirement for higher level care with organ support. Most patients have \u2018physiological\u2019 exertional rhabdomyolysis with no underlying disease; they do not need investigation and should be advised to return to normal activities in a graded fashion. Rarely, exertional rhabdomyolysis may be the initial presentation of underlying muscle disease, and we review how to identify this much smaller group of patients, who do require investigation.<\/jats:p>","DOI":"10.1136\/practneurol-2018-002008","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T12:22:40Z","timestamp":1539174160000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["How to do it: investigate exertional rhabdomyolysis (or not)"],"prefix":"10.1136","volume":"19","author":[{"given":"Peter M","family":"Fernandes","sequence":"first","affiliation":[{"name":"Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Davenport","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"2025090411474896000_19.1.43.1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-203272"},{"key":"2025090411474896000_19.1.43.2","first-page":"502","article-title":"Acute exertional rhabdomyolysis","volume":"52","author":"Line","year":"1995","journal-title":"Am Fam Physician"},{"key":"2025090411474896000_19.1.43.3","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198512000-00010"},{"key":"2025090411474896000_19.1.43.4","first-page":"545","article-title":"How much can exercise raise creatine kinase level \u2014 and does it matter?","volume":"57","author":"Latham","year":"2008","journal-title":"Journal of Family Practice"},{"key":"2025090411474896000_19.1.43.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000130761.78627.10"},{"key":"2025090411474896000_19.1.43.6","article-title":"Exercise-Induced Rhabdomyolysis","volume":"97","author":"Lee","year":"2014","journal-title":"Rhode Island Medical Journal"},{"key":"2025090411474896000_19.1.43.7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13054-016-1376-4","article-title":"The neurological and cognitive consequences of hyperthermia","volume":"20","author":"Walter","year":"2016","journal-title":"Crit Care"},{"key":"2025090411474896000_19.1.43.8","first-page":"767","article-title":"A roman experience with heat stroke in 24 B.C","volume":"43","author":"Jarcho","year":"1967","journal-title":"Bull N Y Acad Med"},{"key":"2025090411474896000_19.1.43.9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1249\/MSS.0b013e3182312745","article-title":"Rhabdomyolysis in the US Active Duty Army, 2004-2006","volume":"44","author":"Hill","year":"2012","journal-title":"Med Sci Sports Exerc"},{"key":"2025090411474896000_19.1.43.10","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000188565.48918.41"},{"key":"2025090411474896000_19.1.43.11","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.4045\/tidsskr.15.1207","article-title":"An increase in the number of admitted patients with exercise-induced rhabdomyolysis","volume":"136","author":"Aalborg","year":"2016","journal-title":"Tidsskr Nor Laegeforen"},{"key":"2025090411474896000_19.1.43.12","doi-asserted-by":"crossref","unstructured":"Tazmini K , Schreiner C , Bruserud S , et al . 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