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We therefore summarise general recommendations and specific advice for anaesthesia in different neuromuscular disorders to provide a comprehensive and accessible overview of the knowledge on this topic essential for clinical neurologists. A preoperative multidisciplinary approach involving anaesthesiologists, cardiologists, chest physicians, surgeons and neurologists is crucial. Depolarising muscle relaxants (succinylcholine) should be avoided at all times. The dose of non-depolarising muscle relaxants must be reduced and their effect monitored. Patients with specific mutations in <jats:italic>RYR1<\/jats:italic> (ryanodine receptor 1) and less frequently in <jats:italic>CACNA1S<\/jats:italic> (calcium channel, voltage-dependent, L type, alpha 1S subunit) and <jats:italic>STAC3<\/jats:italic> (SH3 and cysteine rich domain 3) are at risk of developing a life-threatening malignant hyperthermia reaction.<\/jats:p>","DOI":"10.1136\/practneurol-2020-002633","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T17:21:15Z","timestamp":1603819275000},"page":"12-24","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Anaesthesia and neuromuscular disorders: what a neurologist needs to know"],"prefix":"10.1136","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-3267","authenticated-orcid":false,"given":"Luuk R","family":"van den Bersselaar","sequence":"first","affiliation":[{"name":"Anaesthesiology, Malignant 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