{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:51:54Z","timestamp":1792720314273,"version":"4.5.0"},"reference-count":43,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2019,10,8]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                  <jats:title>Background and objectives<\/jats:title>\n                  <jats:p>The serratus plane block (SPB) is a novel chest wall interfascial plane block. Its analgesic efficacy compared with non-block care and paravertebral block (PVB) is unestablished.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a random-effects meta-analysis of randomized controlled trials (RCTs) recruiting adult surgical patients that compared a SPB to non-block care or PVB for postoperative analgesia. Visual analog scale pain scores were the primary outcome. Database sources were Medline, Embase, the Cochrane Library, and Google Scholar searched up to July 29, 2019 without language restriction. Risk of bias was assessed using Cochrane methodology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nineteen RCTs that comprised 1260 patients were included. Six trials involved thoracic surgery patients and 13 studied breast surgery patients. SPB reduced pain scores 0\u2009hour postoperatively (\u22121.62\u2009cm; 99%\u2009CI \u22122.43 to \u22120.81; p&lt;0.001; I<jats:sup>2<\/jats:sup>=92%), at 2\u20134\u2009hours (\u22121.29\u2009cm; 99%\u2009CI \u22122.08 to \u22120.49; p&lt;0.001; I<jats:sup>2<\/jats:sup>=92%), at 6\u2009hours (\u22121.69\u2009cm; 99%\u2009CI \u22123.19 to \u22120.20; p=0.004; I<jats:sup>2<\/jats:sup>=99%), and up to 24\u2009hours compared with non-block care. SPB also prolonged the time to first analgesic request (193.2\u2009min; 95%\u2009CI 7.2 to 379.2\u2009min; p=0.04; I<jats:sup>2<\/jats:sup>=99%), reduced 24-hour postoperative opioid consumption (\u221211.27\u2009mg of IV morphine equivalent; \u221217.36 to \u22125.18 mg; p&lt;0.001), and reduced postoperative nausea and vomiting (RR 0.51; 95%\u2009CI 0.38 to 0.68; p&lt;0.001; I<jats:sup>2<\/jats:sup>=12%). In contrast, no meaningful differences were detected in any of the outcomes for the SPB versus PVB data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SPB reduced postoperative pain scores (Grading of Recommendations Assessment, Development, and Evaluation rating: low; due to heterogeneity and deficiencies in blinding) in breast and thoracic surgery patients compared with non-block care. Based on five trials only, SPB was not appreciably different from PVB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2019-100982","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T08:52:03Z","timestamp":1571907123000},"page":"1066-1074","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["The serratus plane block for postoperative analgesia in breast and thoracic surgery: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-3119","authenticated-orcid":false,"given":"Matthew","family":"Chong","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Berbenetz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen's University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"2025101111461337000_44.12.1066.1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.redar.2012.07.003","article-title":"Ultrasound description of PecS II (modified PecS I): a novel approach to breast surgery","volume":"59","author":"Blanco","year":"2012","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"2025101111461337000_44.12.1066.2","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000641"},{"key":"2025101111461337000_44.12.1066.3","unstructured":"Ahiskalioglu A , Yayik AM , Demir U , et al . Ultrasound guided bilateral serratus plane block for breast reduction surgery: A randomized controlled double blind study. Reg Anesth Pain Med. Paper presented at the 42nd Annual Regional Anesthesiology and Acute Pain Medicine Meeting, ASRA 2017, United States 2017;42:802\u201318."},{"key":"2025101111461337000_44.12.1066.4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4103\/bmfj.bmfj_162_18","article-title":"Ultrasound-Guided serratus anterior plane block versus thoracic paravertebral block for postmastectomy analgesia","volume":"35","author":"Amin","year":"2018","journal-title":"Benha Medical Journal"},{"key":"2025101111461337000_44.12.1066.5","unstructured":"Arora S , Ovung R , Yaddanapudi S , et al . Efficacy of thoracic paravertebral block versus serratus intercostal plane block for postoperative analgesia in breast cancer surgery. Anesth Analg. 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