{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:24:09Z","timestamp":1762431849758,"version":"build-2065373602"},"reference-count":14,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2020,5,4]]},"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Patient resistance to local anesthetics is rarely considered as the cause of regional anesthesia failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case report<\/jats:title>\n                  <jats:p>We report a case of resistance to local anesthetics in a patient with Crohn\u2019s disease who underwent cesarean section under continuous spinal anesthesia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Resistance to local anesthetics may be more common than we think, especially among patients with chronic pain. Providers should consider local anesthetic resistance when regional anesthesia is unsuccessful. Further research is needed to determine if skin wheal tests and\/or a different local anesthetic could improve results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2020-101516","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T13:56:45Z","timestamp":1590242205000},"page":"669-670","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Local anesthetic resistance in a Crohn\u2019s patient undergoing cesarean delivery"],"prefix":"10.1136","volume":"45","author":[{"given":"Soleil S","family":"Schutte","sequence":"first","affiliation":[{"name":"Anesthesiology, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Euliano","sequence":"additional","affiliation":[{"name":"Anesthesiology, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"2025101109372782000_45.8.669.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199807000-00007"},{"key":"2025101109372782000_45.8.669.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-007-0510-5"},{"key":"2025101109372782000_45.8.669.3","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/BF03011913","article-title":"Failed spinal anaesthesia: cause identified by MRI","volume":"43","author":"Hirabayashi","year":"1996","journal-title":"Can J Anaesth"},{"key":"2025101109372782000_45.8.669.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2006.12.005"},{"key":"2025101109372782000_45.8.669.5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-4-1"},{"key":"2025101109372782000_45.8.669.6","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1213\/00000539-199405000-00031","article-title":"Relative resistance to intrathecal local anesthetics","volume":"78","author":"Bevacqua","year":"1994","journal-title":"Anesth Analg"},{"key":"2025101109372782000_45.8.669.7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00000542-197007000-00024","article-title":"Unexplained failure of a continuous spinal anesthetic","volume":"33","author":"Weiskopf","year":"1970","journal-title":"Anesthesiology"},{"key":"2025101109372782000_45.8.669.8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/bja\/el_1576","article-title":"Resistance to local anaesthetics: a case report","volume":"99","author":"Batas","year":"2007","journal-title":"British Journal of Anesthesia"},{"key":"2025101109372782000_45.8.669.9","first-page":"1089","article-title":"Whole-Exome sequencing of a family with local anesthetic resistance","volume":"82","author":"Clendenen","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"2025101109372782000_45.8.669.10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef163"},{"key":"2025101109372782000_45.8.669.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9270"},{"key":"2025101109372782000_45.8.669.12","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00052.2017"},{"key":"2025101109372782000_45.8.669.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.07.026"},{"key":"2025101109372782000_45.8.669.14","doi-asserted-by":"crossref","unstructured":"Trescot AM . Local anesthetic \"resistance\" 2003;6:291\u20133.","DOI":"10.36076\/ppj.2003\/6\/291"}],"container-title":["Regional Anesthesia &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rapm-2020-101516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T16:37:34Z","timestamp":1760200654000},"score":1,"resource":{"primary":{"URL":"https:\/\/rapm.bmj.com\/lookup\/doi\/10.1136\/rapm-2020-101516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,23]]},"references-count":14,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,7,20]]},"published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1136\/rapm-2020-101516"],"URL":"https:\/\/doi.org\/10.1136\/rapm-2020-101516","relation":{},"ISSN":["1098-7339","1532-8651"],"issn-type":[{"type":"print","value":"1098-7339"},{"type":"electronic","value":"1532-8651"}],"subject":[],"published":{"date-parts":[[2020,5,23]]}}}