{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:12:25Z","timestamp":1760710345290,"version":"3.37.3"},"reference-count":16,"publisher":"BMJ","issue":"10","funder":[{"name":"JSPS KAKENHI","award":["19H03749"],"award-info":[{"award-number":["19H03749"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2020,6,23]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Spinal muscular atrophy (SMA) is an autosomal recessive hereditary neurodegenerative disease causing progressive muscle atrophy, weakness and kyphoscoliosis. Nusinersen is a therapeutic agent for SMA that should be administered intrathecally. However, due to severe kyphoscoliosis, lumbar puncture can be challenging. Here, we present our experience of intrathecal administration of nusinersen in an SMA patient with severe kyphoscoliosis using a life-size three-dimensional printing (3D) skeletal model created with 3D printer. With this strategy, we were able to rapidly and safely perform the lumbar puncture.<\/jats:p>","DOI":"10.1136\/rapm-2020-101607","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T06:05:18Z","timestamp":1597817118000},"page":"757-760","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Use of three-dimensional printing of a lumbar skeletal model for intrathecal administration of nusinersen: a brief technical report"],"prefix":"10.1136","volume":"45","author":[{"given":"Hiroaki","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reo","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-7917","authenticated-orcid":false,"given":"Rikuhei","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hozumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Sumitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"2024120318534038000_45.10.757.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60921-6"},{"key":"2024120318534038000_45.10.757.2","doi-asserted-by":"crossref","DOI":"10.1177\/1756286418803246","article-title":"Feasibility and safety of intrathecal treatment with nusinersen in adult patients with spinal muscular atrophy","volume":"11","author":"Stolte","year":"2018","journal-title":"Ther Adv Neurol Disord"},{"key":"2024120318534038000_45.10.757.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702752"},{"key":"2024120318534038000_45.10.757.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4206-9"},{"key":"2024120318534038000_45.10.757.5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-00644-4","article-title":"Precise treatment of aortic aneurysm by three-dimensional printing and simulation before endovascular intervention","volume":"7","author":"Yuan","year":"2017","journal-title":"Sci Rep"},{"key":"2024120318534038000_45.10.757.6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.21037\/atm.2019.09.73","article-title":"Three-Dimensional printing in structural heart disease and intervention","volume":"7","author":"Fan","year":"2019","journal-title":"Ann Transl Med"},{"key":"2024120318534038000_45.10.757.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2008.11.009"},{"key":"2024120318534038000_45.10.757.8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/MOU.0000000000000274","article-title":"Three-Dimensional printing of surgical anatomy","volume":"26","author":"Powers","year":"2016","journal-title":"Curr Opin Urol"},{"key":"2024120318534038000_45.10.757.9","article-title":"Does Three-dimensional printed patient-specific templates add benefit in revision surgeries for complex pediatric kyphoscoliosis deformity with sublaminar wires in situ ? 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