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The present article reviews the concept of MCID in acute postoperative pain research, addresses potential pitfalls in MCID determination and questions the clinical validity of extrapolating MCID determined from chronic pain and non-surgical pain studies to the acute postoperative pain setting. We further suggest the concepts of minimal clinically important improvement, substantial clinical benefit and patient acceptable symptom state should also represent aspirational outcomes for future research in acute postoperative pain management.<\/jats:p>","DOI":"10.1136\/rapm-2020-101670","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T03:21:04Z","timestamp":1599535264000},"page":"1000-1005","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["Is the minimal clinically important difference (MCID) in acute pain a good measure of analgesic efficacy in regional anesthesia?"],"prefix":"10.1136","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-1580","authenticated-orcid":false,"given":"Felipe","family":"Mu\u00f1oz-Leyva","sequence":"first","affiliation":[{"name":"Department of Anesthesia & Pain Management, University Health Network, University of Toronto, Toronto 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