{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:36:41Z","timestamp":1787017001041,"version":"build-2736575974"},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2020,9,16]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The population of patients scheduled for total laparoscopic hysterectomy at our surgical center is heterogeneous concerning a multitude of demographic variables such as age, collateral surgery and malign or benign pathogenesis. A common denominator is moderate to severe postoperative pain and a substantial opioid consumption. A recent procedure specific postoperative pain management (PROSPECT) review found no gain from the regional techniques included. The transmuscular quadratus lumborum (TQL) block has shown promising results in recent trials for other types of surgery. The aim of the current study was to investigate the analgesic efficacy of the ultrasound-guided TQL block for total laparoscopic hysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 70 patients and randomly allocated participants to preoperative bilateral ultrasound-guided TQL block with either 60\u2009mL 0.375% ropivacaine or 60\u2009mL isotonic saline. Preoperatively, all patients received the TQL block (active or placebo) as well as a standardized multimodal analgesic regimen consisting of oral paracetamol, ibuprofen and dexamethasone. Intraoperatively, intravenous sufentanil 0.2\u2009\u00b5g\/kg was administered 30\u2009min prior to emergence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome<\/jats:title>\n                    <jats:p>Opioid consumption during the first 12 postoperative hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Secondary outcomes<\/jats:title>\n                    <jats:p>Pain scores, times to first opioid demand and first ambulation, nausea and vomiting, and total opioid consumption during the first 24 postoperative hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant intergroup differences were observed for any outcome. Mean (SD) oral morphine equivalent consumption the first 12 postoperative hours was 58.4\u2009mg (48.3) vs 62.9\u2009mg (48.5), p=0.70, for group ropivacaine versus group saline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative bilateral ultrasound-guided TQL block did not reduce opioid consumption after total laparoscopic hysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration numbers<\/jats:title>\n                    <jats:p>NCT 03650998, EudraCT (2017-004593-34).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rapm-2020-101931","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T17:00:35Z","timestamp":1603213235000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Transmuscular quadratus lumborum block for total laparoscopic hysterectomy: a double-blind, randomized, placebo-controlled trial"],"prefix":"10.1136","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1719-9402","authenticated-orcid":false,"given":"Christian","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Dam","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-0445","authenticated-orcid":false,"given":"Martin Vedel","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine B","family":"Tanggaard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels Dirch","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Fichtner","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Aarhus Universitetshospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9839-3812","authenticated-orcid":false,"given":"Jens","family":"B\u00f8rglum","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Clinical Science, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"2025101109220397000_46.1.25.1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2018-100024"},{"key":"2025101109220397000_46.1.25.2","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31825735c6"},{"key":"2025101109220397000_46.1.25.3","doi-asserted-by":"crossref","unstructured":"B\u00f8rglum J , Moriggl B , Jensen K , et al . Letter to the editor. ultrasound-guided transmuscular quadratus lumborum blockade. 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Atlas Der Anatomie des Menschen. 3rd ed. ICON Learning Systems, 2003: p. 157\u2013249."},{"key":"2025101109220397000_46.1.25.12","first-page":"1","article-title":"The peritoneum and its response to surgical injury","volume":"358","author":"diZerega","year":"1990","journal-title":"Prog Clin Biol Res"},{"key":"2025101109220397000_46.1.25.13","unstructured":"Ottesen B , Mogensen O , Forman A . Gyn\u00e6kologi. 4th ed. Copenhagen: Munksgaard, 2011: 33\u20137."},{"key":"2025101109220397000_46.1.25.14","unstructured":"Sinnatamby CS . Last's anatomy: regional and applied. In: Churchill Livingstone. 12th ed, 2011."},{"key":"2025101109220397000_46.1.25.15","unstructured":"Andreasen E , Bierring F , Rostgaard J . De indre organers anatomi. 9th ed. Copenhagen: Munksgaard, 2005: 428\u20139."},{"key":"2025101109220397000_46.1.25.16","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew224"},{"key":"2025101109220397000_46.1.25.17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2017.11.020","article-title":"Incidence of lower-extremity muscle weakness after quadratus lumborum block","volume":"44","author":"Ueshima","year":"2018","journal-title":"J Clin Anesth"}],"container-title":["Regional Anesthesia &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rapm-2020-101931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T16:22:09Z","timestamp":1760199729000},"score":1,"resource":{"primary":{"URL":"https:\/\/rapm.bmj.com\/lookup\/doi\/10.1136\/rapm-2020-101931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12,11]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/rapm-2020-101931"],"URL":"https:\/\/doi.org\/10.1136\/rapm-2020-101931","relation":{},"ISSN":["1098-7339","1532-8651"],"issn-type":[{"value":"1098-7339","type":"print"},{"value":"1532-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]}}}