{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:50:15Z","timestamp":1761709815075,"version":"build-2065373602"},"reference-count":24,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2021,4,12]]},"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Paraplegia is a rare complication of spinal anesthesia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We report a case of a 68-year-old man who developed postoperative paraplegia and hypoesthesia after spinal anesthesia for an otherwise uncomplicated transurethral resection of the prostate. Acute transverse myelitis was diagnosed based on urgent MRI. A prior history of similar though less severe neurological symptoms after obinutuzumab treatment for follicular lymphoma suggested a potential causative role for obinutuzumab, a novel monoclonal antibody that has not been associated with such devastating neurological side effects yet. High-dose steroid treatment partially attenuated the symptoms, but debilitating hypoesthesia and motor deficit remained present 3\u2009months postoperatively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The presented case warrants caution when performing neuraxial anesthesia in patients on monoclonal antibody therapies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2021-102557","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T12:41:32Z","timestamp":1618836092000},"page":"828-830","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Spinal anesthesia in a patient on monoclonal antibody treatment: a poisoned chalice? A case report"],"prefix":"10.1136","volume":"46","author":[{"given":"Anneleen","family":"Herijgers","sequence":"first","affiliation":[{"name":"Anesthesiology, KUL UZ Gasthuisberg, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Van Dyck","sequence":"additional","affiliation":[{"name":"Anesthesiology, KUL UZ Gasthuisberg, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Leroy","sequence":"additional","affiliation":[{"name":"Anesthesiology, Imeldaziekenhuis, Bonheiden, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurens","family":"Dobbels","sequence":"additional","affiliation":[{"name":"Neurology, Imeldaziekenhuis, Bonheiden, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-3101","authenticated-orcid":false,"given":"Peter B C","family":"Van de Putte","sequence":"additional","affiliation":[{"name":"Anesthesiology, Imeldaziekenhuis, Bonheiden, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"2025101111031703000_46.9.828.1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen360"},{"key":"2025101111031703000_46.9.828.2","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000297"},{"key":"2025101111031703000_46.9.828.3","doi-asserted-by":"publisher","DOI":"10.2174\/1568026013395272"},{"key":"2025101111031703000_46.9.828.4","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318244179a"},{"key":"2025101111031703000_46.9.828.5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4103\/0019-5049.158757","article-title":"Prolonged post spinal anaesthesia paralysis","volume":"59","author":"Syal","year":"2015","journal-title":"Indian J Anaesth"},{"key":"2025101111031703000_46.9.828.6","first-page":"656","article-title":"[Magnetic resonance tomography in epidural and subdural spinal hematoma]","volume":"34","author":"Felber","year":"1994","journal-title":"Radiologe"},{"key":"2025101111031703000_46.9.828.7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bja.2017.11.105","article-title":"Haematoma and abscess after neuraxial anaesthesia: a review of 647 cases","volume":"120","author":"Bos","year":"2018","journal-title":"Br J Anaesth"},{"key":"2025101111031703000_46.9.828.8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/22201173.2013.10872949","article-title":"Anaesthetic considerations in patients with transverse myelitis","volume":"19","author":"Balakrishnan","year":"2013","journal-title":"South Afr J Anaesth Analg"},{"key":"2025101111031703000_46.9.828.9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823dc535"},{"key":"2025101111031703000_46.9.828.10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ncl.2012.09.008","article-title":"Transverse myelitis","volume":"31","author":"Beh","year":"2013","journal-title":"Neurol Clin"},{"key":"2025101111031703000_46.9.828.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614598"},{"key":"2025101111031703000_46.9.828.12","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.2217\/fon-2019-0193","article-title":"The role of obinutuzumab in the management of follicular lymphoma","volume":"15","author":"O'Nions","year":"2019","journal-title":"Future Oncol"},{"key":"2025101111031703000_46.9.828.13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5581\/1516-8484.20120015","article-title":"Follicular lymphoma - 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