{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:34Z","timestamp":1787017054851,"version":"build-2736575974"},"reference-count":41,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["MIRROR, HU00011920011"],"award-info":[{"award-number":["MIRROR, HU00011920011"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2021,11,10]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There has been a worldwide surge in interventional procedures for low back pain (LBP), with studies yielding mixed results. These data support the need for identifying outcome predictors based on unique characteristics in a pragmatic setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively evaluated the association between over two dozen demographic, clinical and technical factors on treatment outcomes for three procedures: epidural steroid injections (ESIs) for sciatica, and sacroiliac joint (SIJ) injections and facet interventions for axial LBP. The primary outcome was change in patient-reported average pain intensity on a numerical rating scale (average NRS-PI) using linear regression. For SIJ injections and facet radiofrequency ablation, this was average LBP score at 1 and 3 months postprocedure, respectively. For ESI, it was average leg pain 1- month postinjection. Secondary outcomes included a binary indicator of treatment response (success).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>346 patients were enrolled at seven hospitals. All groups experienced a decrease in average NRS-PI (p&lt;0.0001; mean 1.8\u00b12.6). There were no differences in change in average NRS-PI among procedural groups (p=0.50). Lower baseline pain score (adjusted coefficient \u22120.32, 95% CI \u22120.48 to \u22120.16, p&lt;0.0001), depressive symptomatology (adjusted coefficient 0.076, 95% CI 0.039 to 0.113, p&lt;0.0001) and obesity (adjusted coefficient 0.62, 95% CI 0.038 to 1.21, p=0.037) were associated with smaller pain reductions. For procedural outcome, depression (adjusted OR 0.94, 95% CI 0.91, 0.97, p&lt;0.0001) and poorer baseline function (adjusted OR 0.59, 95% CI 0.36, 0.96, p=0.034) were associated with failure. Smoking, sleep dysfunction and non-organic signs were associated with negative outcomes in univariate but not multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Identifying treatment responders is a critical endeavor for the viability of procedures in LBP. Patients with greater disease burden, depression and obesity are more likely to fail interventions. Steps to address these should be considered before or concurrent with procedures as considerations dictate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02329951\">NCT02329951<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rapm-2021-103247","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T11:56:20Z","timestamp":1638964580000},"page":"89-99","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Multicenter study evaluating factors associated with treatment outcome for low back pain injections"],"prefix":"10.1136","volume":"47","clinical-trial-number":[{"clinical-trial-number":"nct02329951","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5928-2127","authenticated-orcid":false,"given":"Steven P","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"},{"name":"Departments of Physical Medicine & Rehabilitation and Anesthesiology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-3298","authenticated-orcid":false,"given":"Tina L","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Reece","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Dolomisiewicz","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Naval Hospital San Diego, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, VA Puget Sound Health Care System Seattle Division, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jamison","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Surgery, Landstuhl Regional Medical Center, Landstuhl Kirchberg, Rheinland-Pfalz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F","family":"Pasquina","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Walter Reed National Military Medical Center, Bethesda, 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