{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:29:32Z","timestamp":1787725772379,"version":"build-2784847793"},"reference-count":15,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2023,2,9]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This randomized trial compared pericapsular nerve group block and periarticular local anesthetic infiltration in patients undergoing primary total hip arthroplasty. We hypothesized that, compared with pericapsular nerve group block, periarticular local anesthetic infiltration would decrease the postoperative incidence of quadriceps weakness at 3\u2009hours fivefold (ie, from 45% to 9%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sixty patients undergoing primary total hip arthroplasty under spinal anesthesia were randomly allocated to receive a pericapsular nerve group block (n=30) using 20\u2009mL of adrenalized bupivacaine 0.50%, or periarticular local anesthetic infiltration (n=30) using 60\u2009mL of adrenalized bupivacaine 0.25%. Both groups also received 30\u2009mg of ketorolac, either intravenously (pericapsular nerve group block) or periarticularly (periarticular local anesthetic infiltration), as well as 4\u2009mg of intravenous dexamethasone.<\/jats:p>\n                  <jats:p>Postoperatively, a blinded evaluator carried out sensory assessment and motor assessment (knee extension and hip adduction) at 3, 6 and 24 hours. Furthermore, the blinded observer also recorded static and dynamic pain scores at 3, 6, 12, 18, 24, 36 and 48 hours; time to first opioid request; cumulative breakthrough morphine consumption at 24 hours and 48 hours; opioid-related side effects; ability to perform physiotherapy at 6, 24 and 48 hours; as well as length of stay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were no differences in quadriceps weakness at 3\u2009hours between pericapsular nerve group block and periarticular local anesthetic infiltration (20% vs 33%; p=0.469). Furthermore, no intergroup differences were found in terms of sensory block or motor block at other time intervals; time to first opioid request; cumulative breakthrough morphine consumption; opioid-related side effects; ability to perform physiotherapy; and length of stay. Compared with pericapsular nerve group block, periarticular local anesthetic infiltration resulted in lower static pain scores (at all measurement intervals) and dynamic pain scores (at 3 and 6\u2009hours).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>For primary total hip arthroplasty, pericapsular nerve group block and periarticular local anesthetic infiltration result in comparable rates of quadriceps weakness. However, periarticular local anesthetic infiltration is associated with lower static pain scores (especially during the first 24 hours) and dynamic pain scores (first 6\u2009hours). Further investigation is required to determine the optimal technique and local anesthetic admixture for periarticular local anesthetic infiltration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05087862\">NCT05087862<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2023-104332","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T10:30:15Z","timestamp":1676543415000},"page":"489-494","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Randomized clinical trial comparing pericapsular nerve group (PENG) block and periarticular local anesthetic infiltration for total hip arthroplasty"],"prefix":"10.1136","volume":"48","clinical-trial-number":[{"clinical-trial-number":"nct05087862","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05087862","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0611-3623","authenticated-orcid":false,"given":"Daniela","family":"Bravo","sequence":"first","affiliation":[{"name":"Anesthesiology and Perioperative Medicine, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-1270","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Aliste","sequence":"additional","affiliation":[{"name":"Anesthesiology and Perioperative Medicine, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-9609","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Layera","sequence":"additional","affiliation":[{"name":"Anesthesiology and Perioperative Medicine, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Anesthesiology and Perioperative Medicine, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Erpel","sequence":"additional","affiliation":[{"name":"Anesthesiology and Perioperative Medicine, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Anesthesiology and Perioperative Medicine, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n","family":"Arancibia","sequence":"additional","affiliation":[{"name":"Anesthesiology and Perioperative Medicine, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristi\u00e1n","family":"Barrientos","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Wulf","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Bra\u00f1es","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, University of Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-6367","authenticated-orcid":false,"given":"Roderick J","family":"Finlayson","sequence":"additional","affiliation":[{"name":"Pain and Research, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5345-1804","authenticated-orcid":false,"given":"De Q","family":"Tran","sequence":"additional","affiliation":[{"name":"Anesthesiology, McGill University, Montreal, Qu\u00e9bec, 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A randomized, double-blind study","volume":"16","author":"Kuch\u00e1lik","year":"2017","journal-title":"Scand J Pain"},{"key":"2025101111512880000_48.10.489.14","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199911000-00016"},{"key":"2025101111512880000_48.10.489.15","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.arth.2022.03.040","article-title":"Optimizing rapid recovery after anterior hip arthroplasty surgery: a comparative study of fascia iliaca compartment block and local infiltration analgesia","volume":"37","author":"Demeulenaere","year":"2022","journal-title":"J Arthroplasty"}],"container-title":["Regional Anesthesia &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rapm-2023-104332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:51:39Z","timestamp":1760208699000},"score":1,"resource":{"primary":{"URL":"https:\/\/rapm.bmj.com\/lookup\/doi\/10.1136\/rapm-2023-104332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,8,23]]},"published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1136\/rapm-2023-104332"],"URL":"https:\/\/doi.org\/10.1136\/rapm-2023-104332","relation":{},"ISSN":["1098-7339","1532-8651"],"issn-type":[{"value":"1098-7339","type":"print"},{"value":"1532-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}