{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:46:03Z","timestamp":1793353563042,"version":"4.5.0"},"reference-count":35,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2023,9,15]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Injury to saphenous nerve branches is frequent during knee surgery and can result in chronic pain. This saphenous neuralgia remains challenging to treat. Peripheral nerve stimulation (PNS) is a new potential non-pharmacologic treatment option. We present our outcomes experience using this technology in 12 patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively reviewed PNS placement for saphenous neuralgia between 2000 and 2022 at a single institution. Demographic information was collected as well as response to the device. Four-question short-form Patient-Reported Outcome Measurement Information System (PROMIS) Scores were collected before and 2 weeks, 6 weeks, and 6 months postprocedure. Specific scores included pain interference and behavior, functional mobility, depression, anxiety, and sleep impairment. Change in pain interference measured by the short-form PROMIS tool at 6 months was chosen as the primary outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twelve patients met inclusion criteria, with 10 patients having the full 6-month follow-up. In these 10 patients, the mean change from baseline in the short-form adjusted pain interference score (greater difference means improved pain) at 6 months was 5.8 (SD 6.5). Among all patients, average follow-up was 11.5 months (range 3\u201335 months). Most patients\u2019 symptoms developed after knee surgery (84%). Prior to PNS, patients underwent other treatments including cryoablation (8%), radiofrequency ablation (16%), saphenous neurectomy (16%), or surgical release of adjacent nerves (25%). Ten patients (83%) reported any improvement in symptoms while two reported no benefit. Complications occurred in four patients (33%). Two patients had the device removed and a third discontinued use. PROMIS Scores for pain, functional mobility, mood, and sleep impairment all improved.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Limited effective treatments exist for saphenous neuralgia. Our case series demonstrates the potential of PNS as a treatment for saphenous neuralgia. Comparative effectiveness studies are warranted to assess whether our effect size is clinically relevant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2023-104538","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T09:30:23Z","timestamp":1703496623000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Peripheral nerve stimulation for saphenous neuralgia"],"prefix":"10.1136","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-4920","authenticated-orcid":false,"given":"Meghan","family":"McCullough","sequence":"first","affiliation":[{"name":"Surgery, Plastic and Reconstructive Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Kenney","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, Stanford University, Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Curtin","sequence":"additional","affiliation":[{"name":"Surgery, Plastic and Reconstructive Surgery, Stanford University, Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-4303","authenticated-orcid":false,"given":"Einar","family":"Ottestad","sequence":"additional","affiliation":[{"name":"Anesthesiology and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,12,2]]},"reference":[{"key":"2025090415111451000_49.6.455.1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11845-014-1087-2","article-title":"Anatomic study of Infrapatellar branch of saphenous nerve in male cadavers","volume":"184","author":"Kalthur","year":"2015","journal-title":"Ir J Med Sci"},{"key":"2025090415111451000_49.6.455.2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s43166-020-00017-2","article-title":"Frequency of infrapatellar neuropathy post-total knee replacement and arthroscopic surgery in Egyptian patients","volume":"47","author":"Saif","year":"2020","journal-title":"Egypt Rheumatol Rehabil"},{"key":"2025090415111451000_49.6.455.3","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.arth.2016.09.043","article-title":"Selective denervation for persistent knee pain after total knee arthroplasty: a report of 50 cases","volume":"32","author":"Shi","year":"2017","journal-title":"J Arthroplasty"},{"key":"2025090415111451000_49.6.455.4","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1445-2197.2005.03532.x","article-title":"Fate of the infrapatellar branch of the saphenous nerve post total knee arthroplasty","volume":"75","author":"Mistry","year":"2005","journal-title":"ANZ J Surg"},{"key":"2025090415111451000_49.6.455.5","doi-asserted-by":"crossref","unstructured":"Mochida H , Kikuchi S . 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