{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:07:00Z","timestamp":1788923220814,"version":"build-2803163510"},"reference-count":36,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2023,11,3]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Intrathecal analgesia plays a key role for patients suffering refractory cancer pain. Nevertheless, intrathecal drug delivery systems (IDDS), requiring a cervical catheter tip implantation, have been poorly described in medical literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>A monocentric retrospective follow-up study was designed to evaluate results of cervical IDDS for cancer pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and methods<\/jats:title>\n                  <jats:p>From January 2010 to December 2022, all intrathecal-treated patients were prescribed a combined intrathecal analgesics regimen through a catheter placed in the cervical vertebral canal. Post-implant assessment of pain was determined using a numeric rating scale (NRS). Patients were followed via day-hospital visits and telephone calls at least monthly. Pain scores were compared using the Wilcoxon\u2019s signed rank test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ninety-eight patients were included in this study; all received intrathecal treatments. Implanted patients suffered from severe pain (mean presurgical maximum numerical rating score 8.02\u00b10.24 despite a mean 562.56\u00b1127.72\u2009mg of oral morphine equivalent daily dose). Mean survival time after intrathecal treatment start was 208.48\u00b167 days. Intrathecal drug delivery systems provided pain relief compared with initial pain score with a significant statistical difference after 1\u2009week, 1\u2009month, 2 and 3 months (p&lt;0.01). A 50% reduction in initial pain level was achieved in 93% of cases during the first week of intrathecal implant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Results suggest that long-term intrathecal treatment using a multidrug regimen for cancer-related pain through cervical intrathecal catheters was suitable and safe in our study population. We demonstrated a clinically and statistically significant pain reduction in patients using mainly a percutaneous lumbar approach.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2023-104961","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T13:30:39Z","timestamp":1700141439000},"page":"757-763","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Intrathecal cervical analgesia for cancer pain: a 12-year follow-up study in a comprehensive cancer center"],"prefix":"10.1136","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-2130","authenticated-orcid":false,"given":"Denis","family":"Dupoiron","sequence":"first","affiliation":[{"name":"Anesthesiology and Pain Department, Institut de Canc\u00e9rologie de l'Ouest, Angers, 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