{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:17:53Z","timestamp":1793362673928,"version":"4.5.0"},"reference-count":31,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006556","name":"University Hospital Center of Toulouse","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006556","id-type":"DOI","asserted-by":"crossref"}]},{"name":"APICIL","award":["1657.22"],"award-info":[{"award-number":["1657.22"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2024,4,22]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Double-jaw surgeries are known to be painful and to require opioids. Maxillary (V2) and mandibular (V3) nerves block could provide adequate pain management with minimal opioid-related side effects. Our main objective was to evaluate the analgesic effect of bilateral ultrasound-guided V2 and V3 combined nerves block in patients undergoing double-jaw orthognathic surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this single-blind, randomized control study, 50 patients were prospectively allocated to either bilateral ultrasound-guided V2 and V3 combined nerves block or intraoral infiltration of local anesthetic. Primary outcome was the cumulative oral morphine equivalent (OME) consumption assessed at postoperative day 1. Secondary outcomes were cumulative OME consumption and pain scores in recovery room and at postoperative day 2, intraoperative anesthetic consumption, and opioid-related side effects. Preoperative anxiety was investigated by the Amsterdam Preoperative Anxiety and Information Scale (APAIS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with infiltration, ultrasound-guided regional anesthesia reduced cumulative OME consumption on day 1 (45.7\u00b137.6 mg vs 25.5\u00b119.8 mg, respectively, mean difference of \u221220.1 (95% CI \u221237.4 to \u22122.9) mg, p=0.023) and day 2 (64.5\u00b160 mg vs 35.8\u00b130.2 mg, respectively, mean difference of \u221228.7 (95% CI \u221255.9 to \u22121.43) mg, p=0.040). Interestingly, worst pain score and cumulative OME consumptions on day 2 were positively correlated with the APAIS (Pearson\u2019s correlation coefficient of 0.42 (p=0.003) and 0.39 (p=0.006), respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Bilateral ultrasound-guided V2 and V3 combined nerves block reduces postoperative opioid consumption by about 50% in patients undergoing double-jaw surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05351151\">NCT05351151<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2024-105497","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T13:15:48Z","timestamp":1714655748000},"page":"575-580","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Bilateral ultrasound-guided maxillary and mandibular combined nerves block reduces morphine consumption after double-jaw orthognathic surgery: a randomized controlled trial"],"prefix":"10.1136","volume":"50","clinical-trial-number":[{"clinical-trial-number":"nct05351151","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05351151","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8855-0994","authenticated-orcid":false,"given":"Thomas","family":"Esquerr\u00e9","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Perioperative Medicine, University Hospital Centre Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Mure","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Perioperative Medicine, University Hospital Centre Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-4939","authenticated-orcid":false,"given":"Vincent","family":"Minville","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Perioperative Medicine, University Hospital Centre Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-0644","authenticated-orcid":false,"given":"Alice","family":"Prevost","sequence":"additional","affiliation":[{"name":"Department of Plastic and Maxillofacial Surgery, University Hospital Centre Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2893-5954","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Lauwers","sequence":"additional","affiliation":[{"name":"Department of Plastic and Maxillofacial Surgery, University Hospital Centre Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-7454","authenticated-orcid":false,"given":"Fabrice","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Perioperative Medicine, University Hospital Centre Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"2025101111372349000_50.7.575.1","doi-asserted-by":"crossref","first-page":"925e","DOI":"10.1097\/PRS.0000000000004438","article-title":"Current concepts in orthognathic surgery","volume":"141","author":"Naran","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"2025101111372349000_50.7.575.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098548","article-title":"Factors that affect intravenous patient-controlled analgesia for postoperative pain following orthognathic surgery for Mandibular Prognathism","volume":"9","author":"Aoki","year":"2014","journal-title":"PLoS One"},{"key":"2025101111372349000_50.7.575.3","doi-asserted-by":"crossref","unstructured":"Carles M , Beloeil H , Bloc S , et al . Anesth\u00e9sie Loco-R\u00e9gionale P\u00e9rinerveuse (ALR-PN) - Recommandations SFAR. 2019;10.","DOI":"10.1016\/j.anrea.2019.02.003"},{"key":"2025101111372349000_50.7.575.4","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.joms.2018.05.014","article-title":"Postoperative pain and opioid analgesic requirements after orthognathic surgery","volume":"76","author":"Mobini","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"key":"2025101111372349000_50.7.575.5","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1097\/SCS.0000000000008001","article-title":"Decreasing inpatient opioid use following orthognathic surgery","volume":"32","author":"Phillips","year":"2021","journal-title":"J Craniofac Surg"},{"key":"2025101111372349000_50.7.575.6","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.joms.2022.04.002","article-title":"How much opioid medication do patients need after orthognathic 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Investig"}],"container-title":["Regional Anesthesia &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rapm-2024-105497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:37:32Z","timestamp":1760207852000},"score":1,"resource":{"primary":{"URL":"https:\/\/rapm.bmj.com\/lookup\/doi\/10.1136\/rapm-2024-105497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,2]]},"references-count":31,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,4]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/rapm-2024-105497"],"URL":"https:\/\/doi.org\/10.1136\/rapm-2024-105497","relation":{},"ISSN":["1098-7339","1532-8651"],"issn-type":[{"value":"1098-7339","type":"print"},{"value":"1532-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,2]]}}}