{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:15:40Z","timestamp":1793153740666,"version":"4.5.0"},"reference-count":21,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2024,5,10]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Baclofen, a gamma-aminobutyric acid receptor type B agonist in the central nervous system, is the first-line medication among central nervous system modulating agents for the treatment of neurogenic muscle spasticity. While baclofen is most often administered enterally, patients with severe spasticity may be candidates for baclofen delivered by intrathecal pump. Currently, there are only nine studies reporting on the use of intrathecal baclofen (ITB) during pregnancy and childbirth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We described a female patient with a history of childhood idiopathic spasticity of the bilateral lower extremities that was controlled by ITB pump who became pregnant in her late third decade of life and delivered a healthy infant. The patient required multiple increases of her baclofen course over the course of her pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Our case, alongside the existing literature on ITB during pregnancy, suggests that ITB therapy in pregnancy poses a low risk of teratogenicity and infant withdrawal seizures; however, larger, controlled studies are necessary to make those conclusions with confidence. Healthcare providers caring for pregnant ITB patients should be cognizant of the potential for such patients to require increased doses of ITB during pregnancy to achieve adequate symptom control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rapm-2024-105569","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T02:50:24Z","timestamp":1716259824000},"page":"919-922","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Intrathecal baclofen pump in pregnancy: case report, literature review, and management considerations"],"prefix":"10.1136","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1030-2729","authenticated-orcid":false,"given":"Kevin","family":"Yang","sequence":"first","affiliation":[{"name":"USC Keck School of Medicine, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Porus D","family":"Mistry","sequence":"additional","affiliation":[{"name":"USC Keck School of Medicine, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H","family":"Richeimer","sequence":"additional","affiliation":[{"name":"USC Keck School of Medicine, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"2025101111172511000_49.12.919.1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/MRR.0000000000000586","article-title":"Twenty years of intrathecal baclofen therapy in Slovenia: a retrospective single-center analysis of complications","volume":"46","author":"Benedi\u010di\u010d","year":"2023","journal-title":"Int J Rehabil Res"},{"key":"2025101111172511000_49.12.919.2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2021-003184"},{"key":"2025101111172511000_49.12.919.3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/RNJ.0000000000000416","article-title":"Intrathecal baclofen therapy and the role of the rehabilitation nurse","volume":"48","author":"Duraski","year":"2023","journal-title":"Rehabil Nurs"},{"key":"2025101111172511000_49.12.919.4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/j.2048-7940.2008.tb00214.x","article-title":"Intrathecal baclofen therapy in adults and guideline for clinical nursing care","volume":"33","author":"Bhimani","year":"2008","journal-title":"Rehabil Nurs"},{"key":"2025101111172511000_49.12.919.5","doi-asserted-by":"publisher","DOI":"10.1177\/088307389901400611"},{"key":"2025101111172511000_49.12.919.6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/ner.13097","article-title":"Intrathecal baclofen for severe spasticity: longitudinal data from the product surveillance registry","volume":"23","author":"Schiess","year":"2020","journal-title":"Neuromodulation"},{"key":"2025101111172511000_49.12.919.7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2176\/nmccrj.cr.2017-0191","article-title":"Pregnancy and breastfeeding during intrathecal baclofen therapy - a case study and review","volume":"5","author":"Hara","year":"2018","journal-title":"NMC Case Rep J"},{"key":"2025101111172511000_49.12.919.8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.nrl.2014.04.008","article-title":"Intrathecal baclofen for dystonia treatment during pregnancy: a case report","volume":"31","author":"M\u00e9ndez-Lucena","year":"2016","journal-title":"Neurologia"},{"key":"2025101111172511000_49.12.919.9","doi-asserted-by":"publisher","DOI":"10.1258\/om.2010.100016"},{"key":"2025101111172511000_49.12.919.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2009.07.010"},{"key":"2025101111172511000_49.12.919.11","first-page":"21","article-title":"Intrathecal baclofen and pregnancy: implications for clinical care","volume":"31","author":"DeVries-Rizzo","year":"2009","journal-title":"Can J Neurosci Nurs"},{"key":"2025101111172511000_49.12.919.12","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1212\/01.WNL.0000086806.65430.40","article-title":"Intrathecal baclofen pump implantation during pregnancy","volume":"61","author":"Roberts","year":"2003","journal-title":"Neurology"},{"key":"2025101111172511000_49.12.919.13","doi-asserted-by":"crossref","DOI":"10.1345\/aph.18317a","article-title":"Pregnancy outcome in a woman exposed to continuous intrathecal baclofen infusion","volume":"34","author":"Mu\u00f1oz","year":"2000","journal-title":"Ann Pharmacother"},{"key":"2025101111172511000_49.12.919.14","first-page":"527","article-title":"Pregnancy in a Quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe Spasticity","volume":"30","author":"Delhaas","year":"1992","journal-title":"Paraplegia"},{"key":"2025101111172511000_49.12.919.15","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507085552"},{"key":"2025101111172511000_49.12.919.16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijoa.2008.07.001","article-title":"Epidural analgesia in labor for a woman with an intrathecal baclofen pump","volume":"18","author":"Ali Sakr Esa","year":"2009","journal-title":"Int J Obstet Anesth"},{"key":"2025101111172511000_49.12.919.17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00003643-200104000-00009","article-title":"Intrathecal baclofen for severe tetanus in a pregnant woman","volume":"18","author":"Engrand","year":"2001","journal-title":"Eur J Anaesthesiol"},{"key":"2025101111172511000_49.12.919.18","doi-asserted-by":"crossref","DOI":"10.1177\/20503121211022197","article-title":"Baclofen Therapeutics, toxicity, and withdrawal: a narrative review","volume":"9","author":"Romito","year":"2021","journal-title":"SAGE Open Med"},{"key":"2025101111172511000_49.12.919.19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7304.85"},{"key":"2025101111172511000_49.12.919.20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.776"},{"key":"2025101111172511000_49.12.919.21","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c04faf"}],"container-title":["Regional Anesthesia &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rapm-2024-105569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:17:36Z","timestamp":1760206656000},"score":1,"resource":{"primary":{"URL":"https:\/\/rapm.bmj.com\/lookup\/doi\/10.1136\/rapm-2024-105569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":21,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,2]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/rapm-2024-105569"],"URL":"https:\/\/doi.org\/10.1136\/rapm-2024-105569","relation":{},"ISSN":["1098-7339","1532-8651"],"issn-type":[{"value":"1098-7339","type":"print"},{"value":"1532-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]}}}