{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:39:22Z","timestamp":1792798762263,"version":"4.5.0"},"reference-count":31,"publisher":"BMJ","issue":"10","funder":[{"name":"Clinical and Translational Science Institute (CTSI) at the University of Florida, which is supported in part by the NIH National Center for Advancing Translational Sciences","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"https:\/\/ror.org\/04pw6fb54","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100028779","name":"Consortium for Medical Marijuana Clinical Outcomes Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100028779","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute on Aging (NIA)\/National Institute of Health","award":["R01 AG055337"],"award-info":[{"award-number":["R01 AG055337"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2024,6,20]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cannabis use is increasing among older adults, but its impact on postoperative pain outcomes remains unclear in this population. We examined the association between cannabis use and postoperative pain levels and opioid doses within 24 hours of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a propensity score-matched retrospective cohort study using electronic health records data of 22\u2009476 older surgical patients with at least 24-hour hospital stays at University of Florida Health between 2018 and 2020. Of the original cohort, 2577 patients were eligible for propensity-score matching (1:3 cannabis user: non-user). Cannabis use status was determined via natural language processing of clinical notes within 60 days of surgery and structured data. The primary outcomes were average Defense and Veterans Pain Rating Scale (DVPRS) score and total oral morphine equivalents (OME) within 24 hours of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>504 patients were included (126 cannabis users and 378 non-users). The median (IQR) age was 69 (65\u201372) years; 295 (58.53%) were male, and 442 (87.70%) were non-Hispanic white. Baseline characteristics were well balanced. Cannabis users had significantly higher average DVPRS scores (median (IQR): 4.68 (2.71\u20135.96) vs 3.88 (2.33, 5.17); difference=0.80; 95%\u2009confidence limit (CL), 0.19 to 1.36; p=0.01) and total OME (median (IQR): 42.50 (15.00\u201360.00) mg vs 30.00 (7.50\u201360.00) mg; difference=12.5\u2009mg; 95%\u2009CL, 3.80 mg to 21.20\u2009mg; p=0.02) than non-users within 24 hours of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study showed that cannabis use in older adults was associated with increased postoperative pain levels and opioid doses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rapm-2024-105633","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T02:21:47Z","timestamp":1719800507000},"page":"771-778","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Cannabis use and acute postoperative pain outcomes in older adults: a propensity matched retrospective cohort study"],"prefix":"10.1136","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1101-3603","authenticated-orcid":false,"given":"Ruba","family":"Sajdeya","sequence":"first","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Rouhizadeh","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L","family":"Cook","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L","family":"Ison","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Bai","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Jugl","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhi","family":"Gao","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoun T","family":"Mardini","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Dasa","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Zandbiglari","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana I","family":"Adiba","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut G","family":"Winterstein","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C","family":"Price","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Pearson","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph N","family":"Seubert","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J","family":"Tighe","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"2025101111125535000_50.10.771.1","unstructured":"Medicine NA of S Engineering, and, Division H and M, Practice B on PH and PH, Agenda C on the HE of MAER and R . 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Association between cannabis use and postoperative opioid consumption. Abstract presented at: Anesthesiology; New Orleans, LA, 2022 Available: http:\/\/www.asaabstracts.com\/strands\/asaabstracts\/abstract.htm?year=2022&index=17&absnum=6927"},{"key":"2025101111125535000_50.10.771.7","unstructured":"Sajdeya R , Ison RL , Tighe PJ . The anesthetic implications of cannabis use: a propensity-matched retrospective cohort study. 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