{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:25:13Z","timestamp":1793150713769,"version":"4.5.0"},"reference-count":43,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NIH NIDA","award":["R01DA042859"],"award-info":[{"award-number":["R01DA042859"]}]},{"DOI":"10.13039\/100009931","name":"Michigan Department of Health and Human Services","doi-asserted-by":"publisher","award":["E20242492-002"],"award-info":[{"award-number":["E20242492-002"]}],"id":[{"id":"10.13039\/100009931","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2024,11,30]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Previous studies suggest that new persistent opioid use (NPOU) after surgery was associated with larger perioperative opioid prescriptions, but the association between NPOU and postoperative opioid consumption is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included opioid na\u00efve individuals aged 18\u201364 who underwent surgical procedures across 70 Michigan hospitals between July 1, 2018 and November 15, 2021 and were prescribed opioids at discharge. We used clinical and patient-reported opioid consumption data from the Michigan Surgical Quality Collaborative, a statewide surgical registry, linked with the state Prescription Drug Monitoring Program. Multivariable logistic regression modeling was used to assess the association between patient-reported opioid consumption during the 30 days after discharge and NPOU, defined as having an opioid fill during both 31\u2013120\u2009days and 121\u2013210\u2009days after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 36,271 patients included, 482 (1.3%) developed NPOU. These patients consumed more opioid pills in the first 30 days postoperatively than those without NPOU (mean (SD): 7.3 (8.4) 5\u2009mg oxycodone equivalent pills vs 4.1 (5.5), SMD=\u22120.41). In adjusted analyses, each additional opioid pill consumed in the 30-day postoperative period was associated with a 0.05 percentage-point increase in the predicted probability of NPOU (95%\u2009CI 0.04 to 0.07\u2009percentage points). Thus, holding all other variables constant, a 10-pill increase in consumption would be associated with a 0.5 percentage-point increase in the probability of NPOU, or a 38.4% increase relative to the baseline rate of 1.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Demonstrating that opioid consumption in the first 30 days after surgery was independently associated with NPOU underscores the importance of perioperative opioid prescribing on long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rapm-2024-106068","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T20:44:06Z","timestamp":1734986646000},"page":"317-323","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Opioid consumption in the first 30 days after surgery was independently associated with new persistent opioid use"],"prefix":"10.1136","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0516-9257","authenticated-orcid":false,"given":"Brittany A","family":"Ervin-Sikhondze","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhya","family":"Gunaseelan","sequence":"additional","affiliation":[{"name":"Overdose Prevention Engagement Network, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kao-Ping","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Michigan Medicine, Ann Arbor, Michigan, USA"},{"name":"Child Health Evaluation and Research Center, Michigan Medicine, Ann Arbor, Michigan, USA"},{"name":"Opioid Research Institute, Office for the Vice President for Research, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-5953","authenticated-orcid":false,"given":"Mark C","family":"Bicket","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, USA"},{"name":"Overdose Prevention Engagement Network, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer F","family":"Waljee","sequence":"additional","affiliation":[{"name":"Overdose Prevention Engagement Network, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Department of Surgery, Michigan Medicine, Ann Arbor, Michigan, USA"},{"name":"Center for Healthcare Outcomes and Policy, Michigan Medicine, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Englesbe","sequence":"additional","affiliation":[{"name":"Overdose Prevention Engagement Network, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Department of Surgery, Michigan Medicine, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M","family":"Brummett","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, USA"},{"name":"Overdose Prevention Engagement Network, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Opioid Research Institute, Office for the Vice President for Research, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"2026031205150961000_51.3.317.1","doi-asserted-by":"crossref","first-page":"e1225","DOI":"10.1097\/SLA.0000000000005392","article-title":"Postoperative Opioid Prescribing and New Persistent Opioid Use: The Risk of Excessive Prescribing","volume":"277","author":"Howard","year":"2023","journal-title":"Ann Surg"},{"key":"2026031205150961000_51.3.317.2","doi-asserted-by":"crossref","DOI":"10.1186\/s12893-024-02494-0","article-title":"Incidence and risk factors of new persistent opioid use after surgery and trauma: A systematic review","volume":"24","author":"Gong","year":"2024","journal-title":"BMC Surg"},{"key":"2026031205150961000_51.3.317.3","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2017.0504","article-title":"New Persistent Opioid Use After Minor and Major Surgical Procedures in US 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Long-Term Outcomes of Persistent Post-Operative Opioid Use: A Retrospective Cohort Study. 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The Association of Preoperative Opioid Use with Post-Discharge Outcomes: A Cohort Study of the Michigan Surgical Quality Collaborative. 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