{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:07:28Z","timestamp":1788883648518,"version":"build-2803163510"},"reference-count":18,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2025,7,29]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intrathecal drug delivery systems offer a potent modality for managing cancer-related pain that is resistant to conservative measures. However, catheter-related complications, particularly migration, remain a concern. This study assessed the prevalence, risk factors, and implications of catheter migration rates in patients with intrathecal pumps (ITP) for cancer-related pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A retrospective database and chart review of 441 patients with cancer with an ITP at the Huntsman Cancer Institute from May 2014 to December 2023 was performed to identify patients who had two chest CT scans after implant separation by at least 30 days. Catheter migration was defined as movement of the catheter by one or more vertebral levels when comparing the two imaging studies. Demographics were analyzed to identify factors associated with migration. To identify subjects with catheter complications missed by the initial approach, an additional chart review was performed to identify operative procedures linked to catheter revision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>117\u2009patients were suitable for analysis, and 15.4% (n=18) had catheter migration between the two CT scans. These were all limited to a single vertebral level. Across the full cohort of 441\u2009patients, radiographically significant migration requiring revision occurred in only two patients (0.45%). No demographic or clinical factors were significantly associated with migration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Minor catheter migration is relatively common following ITP implantation, but clinically significant migration is rare with the anchoring and closure techniques described.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rapm-2025-106866","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:23:17Z","timestamp":1788880997000},"page":"1028-1033","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Implanted intrathecal pump catheter migration rates in the management of cancer-related pain"],"prefix":"10.1136","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-2980","authenticated-orcid":false,"given":"Gabriel Andres","family":"Martinez Alvarez","sequence":"first","affiliation":[{"name":"Anesthesiology, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-1742","authenticated-orcid":false,"given":"Shane E","family":"Brogan","sequence":"additional","affiliation":[{"name":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W","family":"Odell","sequence":"additional","affiliation":[{"name":"Anesthesiology, University of Utah Health, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill E","family":"Sindt","sequence":"additional","affiliation":[{"name":"Anesthesiology, University of Utah Health, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"2026090808100901000_51.9.1028.1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21834"},{"key":"2026090808100901000_51.9.1028.2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15030591","article-title":"Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis","volume":"15","author":"Snijders","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2026090808100901000_51.9.1028.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.12.340"},{"key":"2026090808100901000_51.9.1028.4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.118"},{"key":"2026090808100901000_51.9.1028.5","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.neurom.2022.03.003","article-title":"Effectiveness and Safety of Intrathecal Drug Delivery Systems for the Management of Cancer Pain: A Systematic Review and Meta-Analysis","volume":"26","author":"Duarte","year":"2023","journal-title":"Neuromodulation"},{"key":"2026090808100901000_51.9.1028.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2021.12.004"},{"key":"2026090808100901000_51.9.1028.7","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.1549","article-title":"Assessment of Health Care Utilization and Cost of Targeted Drug Delivery and Conventional Medical Management vs Conventional Medical Management Alone for Patients With Cancer-Related Pain","volume":"2","author":"Stearns","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2026090808100901000_51.9.1028.8","doi-asserted-by":"crossref","unstructured":"Deer TR , Hayek SM , Grider JS , et al . The Polyanalgesic Consensus Conference (PACC): Updates on Clinical Pharmacology and Comorbidity Management in Intrathecal Drug Delivery for Cancer Pain. Neuromodulation 2024. doi:10.1016\/j.neurom.2024.08.006","DOI":"10.1016\/j.neurom.2024.08.006"},{"key":"2026090808100901000_51.9.1028.9","doi-asserted-by":"crossref","DOI":"10.1016\/j.wneu.2020.04.070","article-title":"Classifying Device-Related Complications Associated With Intrathecal Baclofen Pumps: A MAUDE Study","volume":"139","author":"Abraham","year":"2020","journal-title":"World Neurosurg"},{"key":"2026090808100901000_51.9.1028.10","unstructured":"Medtronic I . Targeted drug delivery systems 2023 medtronic product performance report executive summary. 2023. Available: https:\/\/www.medtronic.com\/content\/dam\/medtronic-wide\/public\/united-states\/products\/neurological\/product-performance-executive-summary-report-targeted-drug-delivery.pdf"},{"key":"2026090808100901000_51.9.1028.11","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.neurom.2022.02.230","article-title":"Dorsal Versus Ventral Intrathecal Catheter Tip Location and Effect on Dose Escalation and Opioid Use in Patients With Cancer Pain","volume":"26","author":"Brogan","year":"2023","journal-title":"Neuromodulation"},{"key":"2026090808100901000_51.9.1028.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(99)00153-0"},{"key":"2026090808100901000_51.9.1028.13","doi-asserted-by":"crossref","first-page":"106630","DOI":"10.1016\/j.clineuro.2021.106630","article-title":"Complications of intrathecal drug delivery therapy (ITDD): A retrospective study of 231 implantations between 1999 and 2014","volume":"205","author":"Necking","year":"2021","journal-title":"Clin Neurol Neurosurg"},{"key":"2026090808100901000_51.9.1028.14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/ner.12538","article-title":"The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines","volume":"20","author":"Deer","year":"2017","journal-title":"Neuromodulation"},{"key":"2026090808100901000_51.9.1028.15","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318203b7c0"},{"key":"2026090808100901000_51.9.1028.16","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181c38da5"},{"key":"2026090808100901000_51.9.1028.17","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200607000-00027"},{"key":"2026090808100901000_51.9.1028.18","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x14666160210142339"}],"container-title":["Regional Anesthesia &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rapm-2025-106866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:23:48Z","timestamp":1788881028000},"score":1,"resource":{"primary":{"URL":"https:\/\/rapm.bmj.com\/lookup\/doi\/10.1136\/rapm-2025-106866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":18,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,8]]},"published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1136\/rapm-2025-106866"],"URL":"https:\/\/doi.org\/10.1136\/rapm-2025-106866","relation":{},"ISSN":["1098-7339","1532-8651"],"issn-type":[{"value":"1098-7339","type":"print"},{"value":"1532-8651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}