{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:57:17Z","timestamp":1787169437536,"version":"build-2736575974"},"reference-count":29,"publisher":"BMJ","funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23 NS125004"],"award-info":[{"award-number":["K23 NS125004"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Reg Anesth Pain Med"],"accepted":{"date-parts":[[2025,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibromyalgia (FM) is a common, disabling, and costly nociplastic pain condition. Most frontline treatments show modest effects in reducing pain in FM, which may be due to a mismatch between the mechanisms of existing interventions and mechanisms underlying nociplastic pain. The current study was a single-arm, open-label trial examining the feasibility, acceptability, and preliminary efficacy of a novel, three-session telehealth behavioral intervention (Brief Pain Reprocessing Therapy (BPRT)). BPRT incorporates psychological techniques specifically targeting the putative mechanisms of nociplastic pain in a brief, telehealth format.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>35 adults with FM initiated treatment. Participants were asked to complete three one-on-one intervention sessions via telehealth and online questionnaires at four time points (pre-intervention and at 1, 2, and 3 months post-intervention) assessing average pain intensity, pain interference, and pain-related fear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>33 participants (94.3%) completed the BPRT protocol. Acceptability ratings for BPRT were high (62.0 out of 70 on the Treatment Acceptability\/Adherence Scale). BPRT completers reported significant reductions in average pain intensity (B=\u22120.645, 95%\u2009CI \u22120.896 to \u22120.395, p&lt;0.001; 1-month d=0.56, 2-month d=0.80, 3-month d=0.89), pain interference (B=\u22122.19, 95%\u2009CI \u22123.06 to \u22121.31, p&lt;0.001; 1-month d=0.76, 2-month d=1.02, 3-month d=1.06), and pain-related fear (B=\u22122.29, 95%\u2009CI \u22123.07 to \u22121.51, p&lt;0.001; 1-month d=0.60, 2-month d=0.88, 3-month d=1.04). At the 3-month follow-up, 42.3% of completers reported being \u2018much improved\u2019 or \u2018very much improved.\u2019<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BPRT is feasible and acceptable, with promising preliminary efficacy for reducing pain, pain interference, and pain-related fear in FM. These findings highlight the possibility of reducing FM pain and interference using a brief telehealth intervention. Larger randomized controlled trials are needed to rigorously evaluate the efficacy and mechanisms of BPRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rapm-2025-107076","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:40:11Z","timestamp":1758264011000},"page":"rapm-2025-107076","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Brief pain reprocessing therapy for fibromyalgia: a feasibility, acceptability, and preliminary efficacy pilot"],"prefix":"10.1136","clinical-trial-number":[{"clinical-trial-number":"nct06208514","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-0920","authenticated-orcid":false,"given":"John","family":"Sturgeon","sequence":"first","affiliation":[{"name":"Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, 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