{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:27:48Z","timestamp":1780662468076,"version":"3.54.1"},"reference-count":34,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2015,4,29]]},"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe changes in drug treatment and clinical outcomes of ankylosing spondylitis (AS) during the past decade.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The national database of the German collaborative arthritis centres collects clinical and patient-derived data from unselected outpatients with inflammatory rheumatic diseases. Cross-sectional data from 2000 to 2012 of around 1000 patients with AS per year were compared with regard to clinical presentation and quality of life indicators.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Non-steroidal anti-inflammatory drugs (NSAIDs) have been the predominant treatment choice in AS over the years with a prescription rate of 67% of patients in 2012. Currently, almost half of the patients with AS in German rheumatology centres are treated with tumour necrosis factor inhibitors (TNFi). Often, both treatments are used in combination (33%), followed by combinations of NSAIDs and synthetic disease modifying antirheumatic drugs (sDMARDs) with 23% or TNFi alone (21%). In 2012, 10% of patients each received NSAID or sDMARD monotherapy. Methotrexate, sulfasalazine, glucocorticoids and analgaesics alone or in combination with other treatments were given to 10% of patients, respectively. Over the years, we have seen remarkable improvements in disease control and patient reported outcomes. These developments are consistent with enhanced functional status, increasing employment rates and decreasing sick leave, hospitalisation and work disability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In the German rheumatology secondary\/tertiary care setting, routine care of patients with AS has changed tremendously during the past decade. Increasingly, more efficacious treatment options are reflected in improved clinical outcomes, quality of life and participation in the labour force.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2014-000033","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T21:32:18Z","timestamp":1432589538000},"page":"e000033","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Trends in treatment and outcomes of ankylosing spondylitis in outpatient rheumatological care in Germany between 2000 and 2012"],"prefix":"10.1136","volume":"1","author":[{"given":"D\u00f6rte","family":"Huscher","sequence":"first","affiliation":[{"name":"Epidemiology Unit, German Rheumatism Research Centre, A Leibniz Institute, Berlin, Germany"},{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Thiele","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, German Rheumatism Research Centre, A Leibniz Institute, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rudwaleit","sequence":"additional","affiliation":[{"name":"Endokrinologikum Berlin am Gendarmenmarkt, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katinka Charlotte","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, German Rheumatism Research Centre, A Leibniz Institute, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Bischoff","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, German Rheumatism Research Centre, A Leibniz Institute, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Immanuel Krankenhaus Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Karberg","sequence":"additional","affiliation":[{"name":"Rheumapraxis Steglitz, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Wassenberg","sequence":"additional","affiliation":[{"name":"Rheumazentrum Ratingen, Ratingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Zink","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, German Rheumatism Research Centre, A Leibniz Institute, Berlin, Germany"},{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 University Hospital Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"2025090313021144000_1.1.e000033.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341003"},{"key":"2025090313021144000_1.1.e000033.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket387"},{"key":"2025090313021144000_1.1.e000033.3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00296-002-0237-4","article-title":"Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis","volume":"23","author":"Feldtkeller","year":"2003","journal-title":"Rheumatol Int"},{"key":"2025090313021144000_1.1.e000033.4","first-page":"613","article-title":"Disability and handicap in rheumatoid arthritis and ankylosing spondylitis\u2014results from the German rheumatological database. 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