{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:26:23Z","timestamp":1757611583239,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2015,4,24]]},"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ossification of the posterior longitudinal ligament (OPLL) of the spine is a common human myelopathy that leads to spinal cord compression. No disease-modifying drug for OPLL has been identified, whereas surgery and conservative management have been established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the therapeutic potential of the H2 blocker famotidine for ectopic ossification in the cervical spine in an OPLL mouse model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The H2 blocker famotidine was orally administered to <jats:italic>Enpp1<\/jats:italic>\n                     <jats:sup>ttw\/ttw<\/jats:sup> mice, a model of OPLL, at either 4 or 15\u2005weeks of age. Radiological and survival rate analyses were performed to assess the effects of famotidine on OPLL-like lesions and mortality in <jats:italic>Enpp1<\/jats:italic>\n                     <jats:sup>ttw\/ttw<\/jats:sup> mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Oral administration of famotidine suppressed the progression of OPLL-like ectopic ossification and reduced mortality in <jats:italic>Enpp1<\/jats:italic>\n                     <jats:sup>ttw\/ttw<\/jats:sup> mice when administration began at 4\u2005weeks of age, early in the development of ossification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study points to the use of famotidine as a disease-modifying drug for ectopic ossification of spinal soft tissue, including OPLL.<\/jats:p>\n               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