{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:10:13Z","timestamp":1790122213298,"version":"4.0.1"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2016,1,15]]},"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Spondyloarthritis (SpA) is a heterogeneous disease with hardly predictable potential courses. We aimed at determining prognostic factors of bad functional outcome at 2\u2005years in patients with early inflammatory back pain (IBP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from patients included in the French multicentre devenir des spondylarthropathies indiff\u00e9renci\u00e9es r\u00e9centes (DESIR) cohort, that is, suffering from IBP starting before 50\u2005years of age and lasting for 3\u201336\u2005months, were used. A bad functional outcome at 24\u2005months was defined as an increase in bath ankylosing spondylitis functional index (BASFI), or BASFI at 2\u2005years higher than the 75th centile in the cohort. Demographic, clinical, biological and radiological data collected at inclusion were compared in patients with bad functional outcome versus others, by \u03c7<jats:sup>2<\/jats:sup> test, then by a multivariate logistic regression model with stepwise selection of relevant factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>513 patients (54.4% females, 72.2% fulfilling ASAS criteria) were assessed. Of those, 130 (25.3%) fulfilled the aforementioned criteria of a bad functional outcome (BASFI increase \u22654\u2005units or \u226536 at 2\u2005years). Multivariate analysis revealed that not fulfilling ASAS criteria, female sex, age &gt;33\u2005years, lower educational level, active smoking status and high disease activity according to bath ankylosing spondylitis disease activity index (BASDAI) at baseline were independently associated with a bad functional outcome at 24\u2005months. Sensitivity analyses restricted to patients fulfilling ASAS criteria for SpA resulted in similar results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We observed, in a large prospective cohort of patients with early IBP, formerly described bad prognostic factors, especially a low educational level, an older age and a high disease activity at onset, and revealed that active smoking status and female sex were also independently associated with a poor outcome. Fulfilment of ASAS criteria, on the other hand, was predictive of a better outcome, most likely due to the more consensual management of a defined disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2015-000204","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T20:49:17Z","timestamp":1454964557000},"page":"e000204","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Factors associated with a bad functional prognosis in early inflammatory back pain: results from the DESIR cohort"],"prefix":"10.1136","volume":"2","author":[{"given":"C","family":"Lukas","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University Hospital Lapeyronie, Montpellier, France"},{"name":"Montpellier University, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dougados","sequence":"additional","affiliation":[{"name":"Department of Rheumatology B, Cochin Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Combe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Lapeyronie, Montpellier University, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"2025090312283815000_2.1.e000204.1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin","year":"1994","journal-title":"J Rheumatol"},{"key":"2025090312283815000_2.1.e000204.2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jbspin.2015.02.006","article-title":"Clinical presentation of patients suffering from recent onset chronic inflammatory back pain suggestive of spondyloarthritis: the DESIR cohort","volume":"82","author":"Dougados","year":"2015","journal-title":"Joint Bone Spine"},{"key":"2025090312283815000_2.1.e000204.3","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett","year":"1994","journal-title":"J Rheumatol"},{"key":"2025090312283815000_2.1.e000204.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094870"},{"key":"2025090312283815000_2.1.e000204.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"2025090312283815000_2.1.e000204.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.21444"},{"key":"2025090312283815000_2.1.e000204.7","first-page":"316","article-title":"Predictors of longterm outcome in ankylosing spondylitis","volume":"30","author":"Doran","year":"2003","journal-title":"J Rheumatol"},{"key":"2025090312283815000_2.1.e000204.8","first-page":"1420","article-title":"Predictors of the progression of functional disability in patients with ankylosing spondylitis","volume":"29","author":"Ward","year":"2002","journal-title":"J Rheumatol"},{"key":"2025090312283815000_2.1.e000204.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev125"},{"key":"2025090312283815000_2.1.e000204.10","doi-asserted-by":"publisher","DOI":"10.1586\/eci.13.35"},{"key":"2025090312283815000_2.1.e000204.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202431"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2015-000204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T19:28:43Z","timestamp":1756927723000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2015-000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,2,8]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1136\/rmdopen-2015-000204"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2015-000204","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}