{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:42:22Z","timestamp":1779162142398,"version":"3.51.4"},"reference-count":18,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2016,3,7]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent has a strongly ageing population and an obesity epidemic; obesity and age both being major risk factors for OA. No adequate therapeutic options, besides joint replacement, are available, although they are greatly needed and should be acquired by adequate research investments. However, the perspective on OA from a researcher's point of view is not always aligned with the perspective of a patient with OA. Researchers base their views on OA mainly on abnormalities in structure and function while patients consider OA as a collection of symptoms. In this viewpoint paper, we discuss the possibility of translating the most important clinical problems into pathophysiological research goals to facilitate the translation from bench to bedside and vice versa. This viewpoint is the outcome of a dialogue within the \u2018European League Against Rheumatism study group on OA\u2019 and People with Arthritis\/Rheumatism across Europe (PARE) representatives.<\/jats:p>","DOI":"10.1136\/rmdopen-2015-000224","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T23:19:35Z","timestamp":1464304775000},"page":"e000224","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Translation of clinical problems in osteoarthritis into pathophysiological research goals"],"prefix":"10.1136","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-3802","authenticated-orcid":false,"given":"Peter M","family":"van der Kraan","sequence":"first","affiliation":[{"name":"Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floris","family":"Lafeber","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, The Section for Rheumatology, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Higginbottom","sequence":"additional","affiliation":[{"name":"EULAR PARE Patient Research Partner and Keele University, Newcastle-under-Lyme, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Ioan-Facsinay","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Loughlin","sequence":"additional","affiliation":[{"name":"Musculoskeletal Research Group, Newcastle University, Institute of Cellular Medicine, The Medical School, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Meulenbelt","sequence":"additional","affiliation":[{"name":"Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva","family":"Moilanen","sequence":"additional","affiliation":[{"name":"The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Pitsillidou","sequence":"additional","affiliation":[{"name":"EULAR PARE Patient Research Partner, Nicosia, 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