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These benefits, however, must be weighed against the increased risk of transplant-related mortality. Further, with disease progression, severe extensive internal organ involvement and damage ensues, constituting an exclusion criterion for safety reasons, leaving a limited window whereby patients with\u00a0SSc are eligible for HSCT. Although autologous HSCT offers the possibility of drug-free remission, relapse can occur, requiring re-initiation of disease modifying antirheumatic drugs. HSCT is also associated with secondary autoimmune diseases and gonadal failure. HSCT should be proposed for carefully selected patients with early rapidly progressive diffuse SSc whose clinical picture portends a poor prognosis for survival, but yet lacks advanced organ involvement.<\/jats:p>","DOI":"10.1136\/rmdopen-2017-000533","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T01:09:55Z","timestamp":1529284195000},"page":"e000533","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Haematopoietic stem cell transplantation in systemic sclerosis"],"prefix":"10.1136","volume":"4","clinical-trial-number":[{"clinical-trial-number":"nct01413100","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ulrich A","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University Hospital Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley Ann","family":"Saketkoo","sequence":"additional","affiliation":[{"name":"Tulane University School of Medicine Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, University Medical Center \u2013 Comprehensive Pulmonary Hypertension Center, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Distler","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,6,17]]},"reference":[{"key":"2025090312094279000_4.1.e000533.1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/rheumatology\/kex182","article-title":"Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group","volume":"57","author":"Jaeger","year":"2018","journal-title":"Rheumatology"},{"key":"2025090312094279000_4.1.e000533.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"2025090312094279000_4.1.e000533.3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211448"},{"key":"2025090312094279000_4.1.e000533.4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209909"},{"key":"2025090312094279000_4.1.e000533.5","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X08317015"},{"key":"2025090312094279000_4.1.e000533.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.4.364"},{"key":"2025090312094279000_4.1.e000533.7","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200106)44:6<1351::AID-ART227>3.0.CO;2-I"},{"key":"2025090312094279000_4.1.e000533.8","doi-asserted-by":"publisher","DOI":"10.1186\/ar2534"},{"key":"2025090312094279000_4.1.e000533.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00232-4"},{"key":"2025090312094279000_4.1.e000533.10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5301\/jsrd.5000207","article-title":"Emerging treatment strategies for systemic sclerosis","volume":"1","author":"Khanna","year":"2016","journal-title":"J Scleroderma Relat Disord"},{"key":"2025090312094279000_4.1.e000533.11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.6.577"},{"key":"2025090312094279000_4.1.e000533.12","unstructured":"Snowden J . 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