{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:58:05Z","timestamp":1760709485326,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009471","name":"EkstraStiftelsen Helse og Rehabilitering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012266","name":"Norsk Revmatikerforbund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012266","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2017,12,1]]},"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the diagnostic spectrum, arthritis persistency and clinical outcomes after 2\u2009years in patients with inflammatory arthritis (IA) of less than 16 weeks\u2019 duration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from the Norwegian Very Early Arthritis Clinic, a 2-year longitudinal observational study of adults with IA of \u226416 weeks\u2019 duration, were used. Exclusion criteria were arthritis due to crystal deposits, trauma, osteoarthritis and septic arthritis. In all patients who had any follow-up information (population A), clinical diagnoses and persistency of arthritis were described. For patients with 2-year follow-up (population B), we also studied other clinical outcomes (disease activity, pain, fatigue, functional disability and health-related quality of life).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In population A (n=1017) median (25th\u201375th percentile) duration of joint swelling was 35.0 (13.0\u201366.5) days, mean (SD) age 45.7 (14.8) years, 55.2% were females and 17.8% anticitrullinated protein antibodies positive. The most common final diagnoses were undifferentiated arthritis (UA) (41.7%), rheumatoid arthritis (RA) (24.1%) and reactive arthritis (18.1%). After 2 years, the arthritis had resolved in 59% of the patients. The remaining 41.0% had persistent disease defined by disease modifying antirheumatic drug (DMARD) use (32.1%) or persistent joint swelling without DMARD use (8.9%). In population B (n=669), all clinical outcomes improved significantly (P&lt;0.001). Baseline joint pain and fatigue were similar across diagnoses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among 1017 patients with IA of \u226416 weeks\u2019 duration, UA was the most common diagnosis after 2 years, and less than one-fourth were diagnosed with RA. Arthritis resolved without DMARDs in the majority of the patients. All clinical parameters improved significantly over a 2-year course.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2017-000573","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T20:13:52Z","timestamp":1514060032000},"page":"e000573","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic spectrum and 2-year outcome in a cohort of patients with very early arthritis"],"prefix":"10.1136","volume":"3","author":[{"given":"Ellen Sauar","family":"Norli","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Martina Hansens Hospital, Sandvika, Norway"},{"name":"Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina Hetland","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway"},{"name":"Department of Rheumatology, \u00d8stfold Hospital Trust, Gr\u00e5lum, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore Kristian","family":"Kvien","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Bj\u00f8rneboe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Martina Hansens Hospital, Sandvika, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Julsrud","family":"Haugen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, \u00d8stfold Hospital Trust, Gr\u00e5lum, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halvor","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathrine","family":"Thunem","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Betanien Hospital, Skien, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Dahl","family":"Mjaavatten","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"2025090312155711000_3.2.e000573.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.78"},{"key":"2025090312155711000_3.2.e000573.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143560"},{"key":"2025090312155711000_3.2.e000573.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.8.700"},{"key":"2025090312155711000_3.2.e000573.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq230"},{"key":"2025090312155711000_3.2.e000573.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.06.001"},{"key":"2025090312155711000_3.2.e000573.6","first-page":"S94","article-title":"The Norfolk Arthritis Register (NOAR)","volume":"21","author":"Symmons","year":"2003","journal-title":"Clin Exp 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prognosis and classification of early arthritis: results of a systematic review informing the 2016 update of the EULAR recommendations for the management of early arthritis","volume":"3","author":"Hua","year":"2017","journal-title":"RMD Open"},{"key":"2025090312155711000_3.2.e000573.19","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"2010","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2025090312155711000_3.2.e000573.20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.11.1096"},{"key":"2025090312155711000_3.2.e000573.21","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201909"},{"key":"2025090312155711000_3.2.e000573.22","first-page":"341","article-title":"Evolution of undifferentiated arthritis: a ten-year experience from 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