{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:26:19Z","timestamp":1757611579004,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"1","funder":[{"name":"The Danish Research Foundation"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2018,4,15]]},"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Radiographic axial spondyloarthritis (r-axSpA) is associated with extracellular matrix (ECM) remodelling of affected tissues. We investigated whether there was a relationship between biomarkers of ECM remodelling and 2-year radiographic progression in r-axSpA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients from the Outcome in Ankylosing Spondylitis International Study (OASIS) were included if they had serum, clinical and spinal radiographic assessments available at baseline and 2\u2009years later. Two readers independently scored the radiographs according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). The average score was used. Type I, V and VI collagen metabolites (C1M, C5M and C6M) and citrullinated and matrix metalloproteinase-degraded vimentin (VICM) were assessed in serum by ELISAs. The relationship between serum biomarkers and 2-year radiographic progression was investigated using linear regression analyses adjusted for potential confounders. Interactions were tested.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients included (n=122) had a mean age of 45 years (SD 12), 70% were male and 82% were human leucocyte antigen-B27 positive. The mean 2-year mSASSS progression was 2.1 (2.9) units. Only C1M was significantly associated with mSASSS progression (\u03b2=0.01, 95%\u2009CI 0.00 to 0.03). The effect disappeared after adjustment for confounders. C5M, C6M and VICM showed no relationship with mSASSS progression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We did not find evidence that degradation of ECM is related to radiographic progression in patients with r-axSpA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2018-000648","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T05:30:09Z","timestamp":1526275809000},"page":"e000648","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Is radiographic progression in radiographic axial spondyloarthritis related to matrix metalloproteinase degradation of extracellular matrix?"],"prefix":"10.1136","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-8422","authenticated-orcid":false,"given":"Anne Sofie","family":"Siebuhr","sequence":"first","affiliation":[{"name":"Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5781-158X","authenticated-orcid":false,"given":"Desir\u00e9e","family":"van der Heijde","sequence":"additional","affiliation":[{"name":"Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-C","family":"Bay-Jensen","sequence":"additional","affiliation":[{"name":"Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten Asser","family":"Karsdal","sequence":"additional","affiliation":[{"name":"Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Amsterdam Rheumatology Center, Amsterdam, The Netherlands"},{"name":"Medical Center, Heerlen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"van Tubergen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center and CAPHRI-School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Ramiro","sequence":"additional","affiliation":[{"name":"Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"2025090313493507000_4.1.e000648.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138883"},{"key":"2025090313493507000_4.1.e000648.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020503"},{"key":"2025090313493507000_4.1.e000648.3","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0127-9"},{"key":"2025090313493507000_4.1.e000648.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2237-8"},{"key":"2025090313493507000_4.1.e000648.5","doi-asserted-by":"publisher","DOI":"10.1186\/ar4266"},{"key":"2025090313493507000_4.1.e000648.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.02.007"},{"key":"2025090313493507000_4.1.e000648.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.30627"},{"key":"2025090313493507000_4.1.e000648.8","first-page":"2030","article-title":"Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis","volume":"35","author":"Maksymowych","year":"2008","journal-title":"J Rheumatol"},{"key":"2025090313493507000_4.1.e000648.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.03.040"},{"key":"2025090313493507000_4.1.e000648.10","doi-asserted-by":"publisher","DOI":"10.1038\/ncb898"},{"key":"2025090313493507000_4.1.e000648.11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.5057"},{"key":"2025090313493507000_4.1.e000648.12","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.012468"},{"key":"2025090313493507000_4.1.e000648.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.21575"},{"key":"2025090313493507000_4.1.e000648.14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090244"},{"key":"2025090313493507000_4.1.e000648.15","first-page":"997","article-title":"Radiological scoring methods in ankylosing spondylitis: reliability and sensitivity to change over one year","volume":"26","author":"Spoorenberg","year":"1999","journal-title":"J Rheumatol"},{"key":"2025090313493507000_4.1.e000648.16","doi-asserted-by":"publisher","DOI":"10.1002\/art.20446"},{"key":"2025090313493507000_4.1.e000648.17","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/acr.22614","article-title":"Hierarchy of impairment of spinal mobility measures in ankylosing spondylitis: twelve-year data","volume":"67","author":"Ramiro","year":"2015","journal-title":"Arthritis Care Res"},{"key":"2025090313493507000_4.1.e000648.18","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2011.620628"},{"key":"2025090313493507000_4.1.e000648.19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024753"},{"key":"2025090313493507000_4.1.e000648.20","first-page":"403","article-title":"Circulating levels of citrullinated and MMP-degraded vimentin (VICM) in liver fibrosis related pathology","volume":"4","author":"Vassiliadis","year":"2012","journal-title":"Am J Transl Res"},{"key":"2025090313493507000_4.1.e000648.21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2217\/bmm.15.119","article-title":"CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis","volume":"10","author":"Siebuhr","year":"2016","journal-title":"Biomark Med"},{"key":"2025090313493507000_4.1.e000648.22","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2014.962024"},{"key":"2025090313493507000_4.1.e000648.23","doi-asserted-by":"publisher","DOI":"10.1002\/art.37843"},{"key":"2025090313493507000_4.1.e000648.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.10.020"},{"key":"2025090313493507000_4.1.e000648.25","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2013.789084"},{"key":"2025090313493507000_4.1.e000648.26","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211989"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2018-000648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:49:42Z","timestamp":1756932582000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2018-000648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,5,14]]},"published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1136\/rmdopen-2018-000648"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2018-000648","relation":{},"ISSN":["2056-5933"],"issn-type":[{"type":"electronic","value":"2056-5933"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}