{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:24:51Z","timestamp":1791563091233,"version":"4.3.4"},"reference-count":50,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/100009471","name":"EkstraStiftelsen Helse og Rehabilitering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2018,9,9]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Psoriatic arthritis (PsA) is associated with an accumulation of cardiovascular disease (CVD) risk factors. The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) on CVD risk factors in patients with PsA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We randomly assigned 61 patients with PsA (41 women and 20 men) to an intervention group performing HIIT for 11 weeks or a control group who were instructed to not change their physical exercise habits. Outcomes were assessed at 3 and 9 \u2009months with measures on maximal oxygen uptake (VO<jats:sub>2max<\/jats:sub>), fat percentage and Body Mass Index (BMI). We used linear mixed models to calculate mean difference with 95% CI between the groups according to the intention-to-treat principle.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At 3 \u2009months, the HIIT group had a 3.72 \u2009mL\/kg\/min (95% \u2009CI 2.38 to 5.06) higher VO<jats:sub>2max<\/jats:sub> and a 1.28 (95% CI \u22122.51 to \u22120.05) lower truncal fat percentage than controls. There was also some evidence that the HIIT group had lower total fat percentage (\u22120.80; 95% \u2009CI \u22121.71 to 0.10) and slightly lower BMI (\u22120.31; 95% \u2009CI \u22120.78 to 0.17) than the control group. At 9 \u2009months, the HIIT group had still a higher VO<jats:sub>2max<\/jats:sub> (3.08; 95% \u2009CI 1.63 to 4.53) than the control group, whereas the difference in other factors were small.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with PsA, 3 \u2009months with HIIT was associated with a substantial increase in VO<jats:sub>2max<\/jats:sub> and a reduction in truncal fat percentage compared with controls. The beneficial effect on VO<jats:sub>2max<\/jats:sub> was also sustained through 9 \u2009months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02995460\">NCT02995460<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2018-000729","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:35:20Z","timestamp":1539304520000},"page":"e000729","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: a randomised controlled trial"],"prefix":"10.1136","volume":"4","clinical-trial-number":[{"clinical-trial-number":"nct02995460","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ruth Stoklund","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Rheumatology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom Ivar Lund","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Anaesthesia and Intensive Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, 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