{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:24:57Z","timestamp":1768782297066,"version":"3.49.0"},"reference-count":14,"publisher":"BMJ","issue":"1","funder":[{"name":"Corrona, LLC"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2019,4,4]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the characteristics of patients with psoriatic arthritis among patient groups stratified by degree of skin and joint involvement, and to evaluate the relationship between skin severity and joint activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Body surface area (BSA) and Clinical Disease Activity Index (CDAI) at enrolment were analysed. Patient characteristics were stratified by skin severity and joint activity. Baseline patient characteristics, clinical and disease characteristics and patient-reported outcomes were compared. The strength of the relationship of skin severity and joint activity was evaluated using methods for categorical variables (\u03c7<jats:sup>2<\/jats:sup> test, Cramer\u2019s V) and continuous variables (linear regression).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>1542 adult patients in the Corrona Psoriatic Arthritis\/Spondyloarthritis Registry enrolled between 21 May 2013 and 20 September 2016 were analysed. Most patients in the BSA &gt;3%\/CDAI moderate\/high subgroup had worse clinical and patient-reported outcomes. A significant (p&lt;0.001) modest association (Cramer\u2019s V=0.1639) between skin severity and joint activity was observed among all patients at enrolment. Patients with higher skin severity were two times more likely to have higher joint involvement (OR 2.27, 95% CI 1.71 to 3.01). A significant linear relationship between CDAI and BSA was observed. Effect modification showed this linear relationship was modified by age, gender, insurance, work status, current therapy, Health Assessment Questionnaire, Nail visual analogue scale, minimal disease activity, dactylitis count, patient-reported pain and fatigue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Skin severity is modestly correlated with joint activity, and patients with higher skin severity are two times more likely to have increased joint involvement. Clinicians need to address both skin severity and joint activity in treatment decisions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2018-000867","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T06:09:22Z","timestamp":1558764562000},"page":"e000867","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Understanding the association between skin involvement and joint activity in patients with psoriatic arthritis: experience from the Corrona Registry"],"prefix":"10.1136","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-0457","authenticated-orcid":false,"given":"Philip J","family":"Mease","sequence":"first","affiliation":[{"name":"Swedish Rheumatology Research Group, Swedish Medical Center and University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol J","family":"Etzel","sequence":"additional","affiliation":[{"name":"Corrona, Waltham, Massachusetts, USA"},{"name":"Department of Epidemiology, UT MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Huster","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia M","family":"Muram","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April W","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R","family":"Lisse","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-4030","authenticated-orcid":false,"given":"Sabrina","family":"Rebello","sequence":"additional","affiliation":[{"name":"Corrona, Waltham, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhiannon","family":"Dodge","sequence":"additional","affiliation":[{"name":"Corrona, Waltham, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mwangi James","family":"Murage","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D","family":"Greenberg","sequence":"additional","affiliation":[{"name":"New York University Hospital for Joint Diseases, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William N","family":"Malatestinic","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"2025090313404209000_5.1.e000867.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/176298","article-title":"Psoriatic arthritis: an update","volume":"2012","author":"Lloyd","year":"2012","journal-title":"Arthritis"},{"key":"2025090313404209000_5.1.e000867.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.032482"},{"key":"2025090313404209000_5.1.e000867.3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jaad.2008.02.040","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics","volume":"56","author":"Gottlieb","year":"2008","journal-title":"J Am Acad Dematol"},{"key":"2025090313404209000_5.1.e000867.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.013"},{"key":"2025090313404209000_5.1.e000867.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.023"},{"key":"2025090313404209000_5.1.e000867.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker365"},{"key":"2025090313404209000_5.1.e000867.7","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/acr.22492","article-title":"Economic and comorbidity burden among moderate-to-severe psoriasis patients with comorbid psoriatic arthritis","volume":"67","author":"Feldman","year":"2015","journal-title":"Arthritis Care & Research"},{"key":"2025090313404209000_5.1.e000867.8","doi-asserted-by":"publisher","DOI":"10.1080\/09546630600823369"},{"key":"2025090313404209000_5.1.e000867.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.9.834"},{"key":"2025090313404209000_5.1.e000867.10","first-page":"1752","article-title":"Baseline relationships between psoriasis and psoriatic arthritis: analysis of 221 patients with active psoriatic arthritis. Department of veterans affairs cooperative study group on seronegative spondyloarthropathies","volume":"26","author":"Cohen","year":"1999","journal-title":"J Rheumatol"},{"key":"2025090313404209000_5.1.e000867.11","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011173"},{"issue":"5 Suppl 39","key":"2025090313404209000_5.1.e000867.12","first-page":"iv37","article-title":"The CORRONA database","volume":"23","author":"Kremer","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"2025090313404209000_5.1.e000867.13","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2626-y"},{"key":"2025090313404209000_5.1.e000867.14","first-page":"S14","article-title":"Measures of rheumatoid arthritis disease activity: patient (PtGA) and provider (PrGA) global assessment of disease activity, disease activity score (DAS) and disease activity score with 28-Joint counts (DAS28), simplified disease activity index (SDAI), clinical disease activity index (CDAI), patient activity score (PAS) and patient activity Score-II (PASII), routine assessment of patient index data (Rapid), rheumatoid arthritis disease activity index (radai) and rheumatoid arthritis disease activity Index-5 (RADAI-5), chronic arthritis systemic index (CASI), patient-based disease activity score with ESR (PDAS1) and patient-based disease activity score without ESR (PDAS2), and mean overall index for rheumatoid arthritis (MOI-RA)","volume":"63 Suppl 11","author":"Anderson","year":"2011","journal-title":"Arthritis Care Res"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2018-000867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:40:47Z","timestamp":1756932047000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2018-000867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,5,24]]},"published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1136\/rmdopen-2018-000867"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2018-000867","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}