{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:17:25Z","timestamp":1778815045057,"version":"3.51.4"},"reference-count":30,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/100020908","name":"Pfizer France","doi-asserted-by":"crossref","award":["Passerelle Bursary"],"award-info":[{"award-number":["Passerelle Bursary"]}],"id":[{"id":"10.13039\/100020908","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100019016","name":"Assessment of SpondyloArthritis international Society","doi-asserted-by":"crossref","award":["ASAS research grant"],"award-info":[{"award-number":["ASAS research grant"]}],"id":[{"id":"10.13039\/100019016","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2019,4,8]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the prevalence and performance as axial Spondyloarthritis (axSpA) diagnostic feature of radiographic and MRI lesions \u2018typical\u2019 of axSpA of the sacroiliac joint (SIJ) and spine in a mechanical chronic back pain (CBP) population and in an axSpA cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional multicentre study. Patients: (1) recent onset axSpA (DESIR cohort) and (2) mechanical non-axSpA CBP matched for age and gender (ILOS study). Imaging: radiographs and MR scans were performed identically in both groups. All images were centrally read, blinded for diagnosis and for other imaging findings in the same patient. Statistical analysis: prevalence of lesions \u2018typical of axSpA\u2019 were compared in both groups. Sensitivity, specificity and positive likelihood ratios (LR+) of each lesion (and combination of lesions) were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 98 patients with CBP were included, and compared with 100 patients with recent onset axSpA. SIJ lesions were consistently more frequent in the axSpA group (35.0% vs 11.8%\u2009p&lt;0.001, 35.0% vs 8.4%\u2009p&lt;0.001%\u2009and 32.0% vs 10.0%. p&lt;0.001 for modified New York criteria, MRI sacroiliitis and \u22653 erosions of the SIJ on MRI, respectively), and performed well (LR+ for \u22653 erosions 3.0 (95% CI 1.6 to 5.8)). Spine lesions were comparable across groups: radiographic lesions were rare, while all MRI lesions were frequent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study confirms that \u2018typical\u2019 lesions can also be observed in patients with non-axSpA CBP but that SIJ lesions by all modalities remain the most valuable for diagnosis, including structural lesions of the SIJ. This suggests the potential interest of adding MRI SIJ structural lesions in the definition of MRI abnormalities for axSpA classification.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2019-000918","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T08:24:23Z","timestamp":1559118263000},"page":"e000918","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of the performances of \u2018typical\u2019 imaging abnormalities of axial spondyloarthritis: results of the cross-sectional ILOS-DESIR study"],"prefix":"10.1136","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-1986","authenticated-orcid":false,"given":"Anna","family":"Molto","sequence":"first","affiliation":[{"name":"Rheumatology, Hopital Cochin, Paris, France"},{"name":"INSERM (U1153): Clinical Epidemiology and Biostatistics PRES Sorbonne Paris-Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-310X","authenticated-orcid":false,"given":"Laure","family":"Gossec","sequence":"additional","affiliation":[{"name":"INSERM UMR S1136, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Sorbonne Universit\u00e9, Paris, France"},{"name":"Rheumatology, Hopital Universitaire Pitie Salpetriere, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Martine","family":"Lef\u00e8vre-Colau","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation, Cochin Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violaine","family":"Foltz","sequence":"additional","affiliation":[{"name":"Rheumatology, Hopital Universitaire Pitie Salpetriere, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Beaufort","sequence":"additional","affiliation":[{"name":"Private Practice, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Denis","family":"Laredo","sequence":"additional","affiliation":[{"name":"Radiology, Lariboisi\u00e8re Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-4074","authenticated-orcid":false,"given":"Pascal","family":"Richette","sequence":"additional","affiliation":[{"name":"Rheumatology, Hopital Lariboisiere, Paris, France"},{"name":"Inserm UMR1132 Bioscar, Universite Paris Diderot UFR de Medecine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Dieude","sequence":"additional","affiliation":[{"name":"Rheumatology, CHU Bichat Claude Bernard, Paris, France"},{"name":"INSERM U699, Bichat Faculty of Medicine, Universit\u00e9 Paris Diderot, PRES Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Goupille","sequence":"additional","affiliation":[{"name":"Rheumatology, Trousseau University Hospital, Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Feydy","sequence":"additional","affiliation":[{"name":"Radiology Department, Cochin Hospital, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[{"name":"Rheumatology, Hopital Cochin, Paris, France"},{"name":"INSERM (U1153): Clinical Epidemiology and Biostatistics PRES Sorbonne Paris-Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"2025090313280560000_5.1.e000918.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211734"},{"key":"2025090313280560000_5.1.e000918.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"2025090313280560000_5.1.e000918.3","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/ard.2008.104018","article-title":"The assessment of spondyloarthritis International Society (ASAS) Handbook: a guide to assess spondyloarthritis","volume":"68 Suppl 2","author":"Sieper","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"2025090313280560000_5.1.e000918.4","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200007000-00002"},{"key":"2025090313280560000_5.1.e000918.5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jbspin.2016.06.005","article-title":"Diagnostic delay in axial spondyloarthritis: A cross-sectional study of 432 patients","volume":"84","author":"Masson Behar","year":"2017","journal-title":"Joint Bone Spine"},{"key":"2025090313280560000_5.1.e000918.6","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1002\/art.38738","article-title":"Agreement between clinical practice and trained central reading in reading of sacroiliac joints on plain pelvic radiographs. Results from the DESIR cohort","volume":"66","author":"van den Berg","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2025090313280560000_5.1.e000918.7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.6.519"},{"key":"2025090313280560000_5.1.e000918.8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208642"},{"key":"2025090313280560000_5.1.e000918.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110767"},{"key":"2025090313280560000_5.1.e000918.10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108217"},{"key":"2025090313280560000_5.1.e000918.11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"2025090313280560000_5.1.e000918.12","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204262"},{"key":"2025090313280560000_5.1.e000918.13","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210747"},{"key":"2025090313280560000_5.1.e000918.14","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000303","article-title":"What is the reliability of non-trained Investigators in recognising structural MRI lesions of sacroiliac joints in patients with recent inflammatory back pain? Results of the DESIR cohort","volume":"2","author":"Jacquemin","year":"2016","journal-title":"RMD Open"},{"key":"2025090313280560000_5.1.e000918.15","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s10067-017-3643-4","article-title":"Assessment of typical spa lesions on MRI of the spine: do local readers and central readers agree in the DESIR-cohort at baseline?","volume":"36","author":"de Hooge","year":"2017","journal-title":"Clin Rheumatol"},{"key":"2025090313280560000_5.1.e000918.16","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209405"},{"key":"2025090313280560000_5.1.e000918.17","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/acr.20312","article-title":"Assessment of structural lesions in sacroiliac joints enhances diagnostic utility of magnetic resonance imaging in early spondylarthritis","volume":"62","author":"Weber","year":"2010","journal-title":"Arthritis Care Res"},{"key":"2025090313280560000_5.1.e000918.18","doi-asserted-by":"crossref","unstructured":"Weber U , Jurik AG , Zejden A , et al . Frequency and Anatomic Distribution of Magnetic Resonance Imaging Features in the Sacroiliac Joints of Young Athletes: Exploring \"Background Noise\" Toward a Data-Driven Definition of Sacroiliitis in Early Spondyloarthritis. Arthritis Rheumatol 2018;70.doi:10.1002\/art.40429","DOI":"10.1002\/art.40429"},{"key":"2025090313280560000_5.1.e000918.19","unstructured":"A positive MRI of the Sacroiliac joints is not specific for axial spondyloarthritis but frequently occurs in healthy individuals. ACR meeting Abstracts. Available: http:\/\/acrabstracts.org\/abstract\/a-positive-mri-of-the-sacroiliac-joints-is-not-specific-for-axial-spondyloarthritis-but-frequently-occurs-in-healthy-individuals\/ [Accessed 6 Mar 2018]."},{"key":"2025090313280560000_5.1.e000918.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.02.006"},{"key":"2025090313280560000_5.1.e000918.21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020503"},{"key":"2025090313280560000_5.1.e000918.22","doi-asserted-by":"publisher","DOI":"10.1002\/art.21445"},{"key":"2025090313280560000_5.1.e000918.23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207823"},{"key":"2025090313280560000_5.1.e000918.24","doi-asserted-by":"publisher","DOI":"10.1002\/art.21337"},{"key":"2025090313280560000_5.1.e000918.25","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150680"},{"key":"2025090313280560000_5.1.e000918.26","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090617"},{"key":"2025090313280560000_5.1.e000918.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2012.10.005"},{"key":"2025090313280560000_5.1.e000918.28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2002.10750.x"},{"key":"2025090313280560000_5.1.e000918.29","unstructured":"R: the R project for statistical computing. Available: https:\/\/www.r-project.org\/ [Accessed 8 Mar 2019]."},{"key":"2025090313280560000_5.1.e000918.30","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205432"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2019-000918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:28:14Z","timestamp":1756931294000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2019-000918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,5,28]]},"published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1136\/rmdopen-2019-000918"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2019-000918","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}